Molecules 2010, 15(6), 4242-4260; doi:10.3390/molecules15064242
Review

Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction

Motoo Tori* email and Reiko Mizutani
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770-8514, Japan
* Author to whom correspondence should be addressed.
Received: 21 May 2010; in revised form: 7 June 2010 / Accepted: 10 June 2010 / Published: 11 June 2010
(This article belongs to the Special Issue Ring-Closing Metathesis)
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Abstract: Medium sized carbocycles are particularly difficult to synthesize. Ring closing metathesis reactions (RCM) have recently been applied to construct eight-membered carbocycles, but trisubstituted double bonds in the eight-membered rings are more difficult to produce using RCM reactions. In this review, model examples and our own results are cited and the importance of the preparation of suitably designed precursors is discussed. Examples of RCM reactions used in the total synthesis of natural products are also outlined.
Keywords: ring closing metathesis; eight-membered carbocycles; synthesis

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Cite This Article

MDPI and ACS Style

Tori, M.; Mizutani, R. Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction. Molecules 2010, 15, 4242-4260.

AMA Style

Tori M, Mizutani R. Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction. Molecules. 2010; 15(6):4242-4260.

Chicago/Turabian Style

Tori, Motoo; Mizutani, Reiko. 2010. "Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction." Molecules 15, no. 6: 4242-4260.

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