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Construction of Eight-Membered Carbocycles with Trisubstituted Double Bonds Using the Ring Closing Metathesis Reaction
Molecules 2010, 15(7), 5045-5052; doi:10.3390/molecules15075045

Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones

1, 1, 2,* , 2 and 3
1 School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 2 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China 3 College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, Guilin, China
* Author to whom correspondence should be addressed.
Received: 4 June 2010 / Revised: 24 June 2010 / Accepted: 5 July 2010 / Published: 23 July 2010
(This article belongs to the Special Issue Ring-Closing Metathesis)
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We have developed a Pt(COD)Cl2-catalyzed hydrative cyclization of 1,6-diynes leading to the formation of functionalized cyclohexenones in good yields.
Keywords: diyne; catalysis; hydrative cyclization; cyclohexenones diyne; catalysis; hydrative cyclization; cyclohexenones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, C.; Qi, J.-F.; Cui, D.-M.; Wang, Q.; Wang, X.-L. Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones. Molecules 2010, 15, 5045-5052.

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