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Molecules 2010, 15(7), 5045-5052; doi:10.3390/molecules15075045

Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones

1, 1, 2,* , 2 and 3
1 School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China 2 College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China 3 College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi, Guilin, China
* Author to whom correspondence should be addressed.
Received: 4 June 2010 / Revised: 24 June 2010 / Accepted: 5 July 2010 / Published: 23 July 2010
(This article belongs to the Special Issue Ring-Closing Metathesis)
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We have developed a Pt(COD)Cl2-catalyzed hydrative cyclization of 1,6-diynes leading to the formation of functionalized cyclohexenones in good yields.
Keywords: diyne; catalysis; hydrative cyclization; cyclohexenones diyne; catalysis; hydrative cyclization; cyclohexenones
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, C.; Qi, J.-F.; Cui, D.-M.; Wang, Q.; Wang, X.-L. Platinum-Catalyzed Hydrative Cyclization of 1,6-Diynes for the Synthesis of 3,5-Substituted Conjugated Cyclohexenones. Molecules 2010, 15, 5045-5052.

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