Recent Advances in Diversity-Oriented Synthesis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Molecular Diversity".
Deadline for manuscript submissions: closed (31 August 2014) | Viewed by 22592
Special Issue Editor
Interests: diversity oriented synthesis; medicinal chemistry; drug discovery; chemical technology; infectious diseases
Special Issue Information
Dear Colleagues,
Historically, small-molecule screening collections have tended to be heavily populated with achiral, aromatic compounds that can be prepared efficiently and at low cost, but which occupy a narrow region of chemical space. These collections have led to major contributions to our drug pharmacopeia, but have not produced useful leads for numerous targets. This failure has led to the outlook that we may not be able to find pharmaceuticals for such targets.
However, we have recently witnessed the emergence of many innovative strategies for the assembly of chemically diverse libraries that cover a much broader region of chemical space. Diversity-oriented synthesis offers a systematic and efficient strategy to synthesize collections of structurally complex and functionally diverse small molecules that may ultimately exert their biological effects through unique mechanisms. DOS libraries have various common features, such as an increased ratio of sp3-hybridized atoms and a greater number of stereogenic elements relative to conventional compound libraries. These collections combine the structural complexity of natural products with the efficiency of high-throughput synthesis. These new diverse molecular scaffolds are leading to remarkable advances in chemistry and biology.
For this Special Issue, we invite the submission of manuscripts focusing on current investigations in the field of DOS, such as the development and evaluation of new synthetic strategies and approaches, and the application of these diverse molecular scaffolds in probing new biology.
Dr. Eamon Comer
Guest Editor
Manuscript Submission Information
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Keywords
- diversity-oriented synthesis
- asymmetric synthesis
- next generation synthesis
- stereodivergence and stereoselectivity
- chemical library synthesis
- probe molecules
- biologically active molecules
- drug discovery
- molecular scaffolds
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