Special Issue "Radiochemistry"

Guest Editor
Dr. Svend Borup Jensen
Nuklearmedicinsk Afdeling - Hobrovej 18-22, Postboks 365, 9100 Aalborg, Denmark
E-Mail:
Phone: +45 9932 3140
Fax: +45 9932 3145
Interests: drug in-vitro degradation profiles; medicinal gum; analytical methods; medicinal chemistry; PET-radiochemistry

Dear Colleagues,

Radiochemistry is the chemistry of radioactive materials. The research interest in this field of chemistry has experienced a big growth during the last decades, driven by a demand of being able to visualize biological processes in the human body. This special issue of Molecules, dedicated to radiochemistry, calls for both fundamental and applied contributions in this field of growing academic and industrial interests. Special attention will be paid to paper which has a high degree of novelty, which can contribute to making everyday life easier for radio chemists, which can have a (potential) diagnostic impact or/and which contribute to the understanding of biological processes in vivo.

Dr. Svend Borup Jensen
Guest Editor

Related Special Issues in other Journals

Radiochemistry in Pharmaceuticals

Submission

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• incorporation of radioactive isotopes into biological interesting compounds
• radioactive labeled compounds metabolic pathway
• synthesis of precursor and reference materials
• quality control of radiopharmaceuticals
• purification technics
• non-commercial equipment
• PET molecules
• SPEC molecules

Type of Paper: Review
Title: Detection and Quantification of Radionucleotide Incorporations into Biological Systems Using Microchannel Plate Autoradiographic Imagers
Authors: Wayne G. Carter ¹, Vasanthy Vigneswara ¹, Mabruka H. Tarhoni ¹, Johnathon Lees ², Kim Travis ³ and David E. Ray ¹
Affiliations: ¹ School of Biomedical Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham, Nottinghamshire, NG7 2UH, UK; E-Mail: Wayne.Carter@Nottingham.ac.uk (W.G.C.)
² BioImaging Unit, Space Research Centre, Department of Physics & Astronomy, University of Leicester, Leicester, LE1 7RH, UK
³ Syngenta, Jealott’s Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK
Abstract: Radionucleotides have been utilised as molecular tracers to study biological systems for over seventy years. Autoradiographic detection and quantification of radionucleotide incorporations has survived over that period as a useful technique to dissect biological processes. In this review-style article we describe the advantageous properties of microchannel plate (MCP) autoradiographic imagers to detect tracer radionucleotides. These include a signal detection threshold of 6 dpm/mm², and production of autoradiographic images in real-time over six orders of signal magnitude; traits that render MCP devices superior to conventional film autoradiography. We also present novel data that exploits the MCP technology for the detection and quantification of organophosphorus radiolabel incorporations into proteins after in vitro radiolabelling, and also tissue sections after in vivo animal dosing.