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Molecules 2011, 16(1), 818-846; doi:10.3390/molecules16010818
Article

Specific Radioactivity of Neutron Induced Radioisotopes: Assessment Methods and Application for Medically Useful 177Lu Production as a Case

Received: 25 November 2010; in revised form: 10 January 2011 / Accepted: 17 January 2011 / Published: 19 January 2011
(This article belongs to the Special Issue Radiochemistry)
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Abstract: The conventional reaction yield evaluation for radioisotope production is not sufficient to set up the optimal conditions for producing radionuclide products of the desired radiochemical quality. Alternatively, the specific radioactivity (SA) assessment, dealing with the relationship between the affecting factors and the inherent properties of the target and impurities, offers a way to optimally perform the irradiation for production of the best quality radioisotopes for various applications, especially for targeting radiopharmaceutical preparation. Neutron-capture characteristics, target impurity, side nuclear reactions, target burn-up and post-irradiation processing/cooling time are the main parameters affecting the SA of the radioisotope product. These parameters have been incorporated into the format of mathematical equations for the reaction yield and SA assessment. As a method demonstration, the SA assessment of 177Lu produced based on two different reactions, 176Lu (n,γ)177Lu and 176Yb (n,γ) 177Yb (β- decay) 177Lu, were performed. The irradiation time required for achieving a maximum yield and maximum SA value was evaluated for production based on the 176Lu (n,γ)177Lu reaction. The effect of several factors (such as elemental Lu and isotopic impurities) on the 177Lu SA degradation was evaluated for production based on the 176Yb (n,γ) 177Yb (β- decay) 177Lu reaction. The method of SA assessment of a mixture of several radioactive sources was developed for the radioisotope produced in a reactor from different targets.
Keywords: specific radioactivity; target burn-up; isotope dilution; neutron capture yield; nuclear reaction ; nuclear reactor; radioisotope production; targeting radiopharmaceutical; 177Lu; 175Lu; 176Lu; 177Yb; 176Yb; 175Yb; 174Yb   specific radioactivity; target burn-up; isotope dilution; neutron capture yield; nuclear reaction; nuclear reactor; radioisotope production; targeting radiopharmaceutical; 177Lu; 175Lu; 176Lu; 177Yb; 176Yb; 175Yb; 174Yb  
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Le, V.S. Specific Radioactivity of Neutron Induced Radioisotopes: Assessment Methods and Application for Medically Useful 177Lu Production as a Case. Molecules 2011, 16, 818-846.

AMA Style

Le VS. Specific Radioactivity of Neutron Induced Radioisotopes: Assessment Methods and Application for Medically Useful 177Lu Production as a Case. Molecules. 2011; 16(1):818-846.

Chicago/Turabian Style

Le, Van So. 2011. "Specific Radioactivity of Neutron Induced Radioisotopes: Assessment Methods and Application for Medically Useful 177Lu Production as a Case." Molecules 16, no. 1: 818-846.


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