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Special Issue "Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editor

Guest Editor
Prof. Katherine L. Seley-Radtke

Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD, USA
Website | E-Mail
Interests: nucleos(t)ides; heterocycles; drug design; enzyme inhibitors; antiviral

Special Issue Information

Dear Colleagues,

For decades, nucleosides and nucleotides have formed the cornerstone of antiviral and anticancer therapeutics. In addition, some analogues have also made progress against parasites and bacteria and in other areas. This phenomenon is a direct result of their close structural similarity to naturally occurring nucleosides. As such, any changes to their diverse scaffolds can have profound effects. In general, nucleoside and nucleotide analogues target key biological pathways in the replication cycles of many diseases; However, some have also been shown to target human enzymes, which can sometimes result in deleterious consequences. In this regard, the primary issue with this class of drugs involves selectivity. A second major issue with this class of drugs is the often-times rapid development of resistance. As a result, there is a constant need for new and more effective analogues to fight emerging and reemerging infectious diseases and cancers; thus, this Special Issue will focus on some of the leading approaches to design, synthesis, and biological investigations, as well as the various applications for this highly relevant class of compounds and their corresponding prodrugs.

Prof. Katherine Seley-Radtke
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nucleosides
  • Nucleotides
  • Prodrugs
  • Antiviral
  • Anticancer
  • Enzyme inhibitors

Published Papers

This special issue is now open for submission.
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