Special Issue "Multicomponent Reaction"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 December 2012)
Dr. Irini Akritopoulou-Zanze
Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA
Interests: drug discovery; de novo design and synthesis of biologically active scaffolds; focused compound libraries; multicomponent reactions
Multicomponent reactions (MCRs) are powerful transformations that incorporate portions of three or more reactants into new products in one pot procedures. They have been used extensively to form heterocyclic structures and they have been combined with subsequent transformations to yield complex structures, not easily accessible via classical synthetic reactions.
Efforts to discover new MCRs or further develop older ones, especially in combination with other transformations, contribute significantly to the advancement of organic synthesis by providing greater flexibility, novelty and efficiency. Applications of MCRs in drug discovery, material sciences, natural product synthesis and ligand and biological probe preparations further demonstrate the power of these reactions. Advances in cheminformatic tools allow for virtual MCR libraries to be first accessed in silico against a variety of different parameters before initiation of compound library synthesis.
This special issue of Molecules welcomes previously unpublished manuscripts covering all aspects of multicomponent reactions including their design, product assessment, methodology development and applications.
Dr. Irini Akritopoulou-Zanze
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
- multicomponent reactions
- isocyanide-based MCRS
- heterocycle forming MCRS
- library design
- library synthesis
- parallel synthesis
- novel scaffolds
- biologically active molecules
- post MCR transformations
Article: Divergent Synthesis of Novel Five-Membered Heterocyclic Compounds by Base-Mediated Rearrangement of Acrylamides Derived from a Novel Isocyanide-Based Multicomponent Reaction
Molecules 2011, 16(10), 8775-8787; doi:10.3390/molecules16108775
Received: 21 September 2011; in revised form: 3 October 2011 / Accepted: 11 October 2011 / Published: 19 October 2011| Download PDF Full-text (237 KB)
Molecules 2011, 16(10), 8815-8832; doi:10.3390/molecules16108815
Received: 17 August 2011; in revised form: 11 October 2011 / Accepted: 12 October 2011 / Published: 20 October 2011| Download PDF Full-text (343 KB)
Molecules 2011, 16(11), 9161-9177; doi:10.3390/molecules16119161
Received: 13 September 2011; in revised form: 18 October 2011 / Accepted: 21 October 2011 / Published: 2 November 2011| Download PDF Full-text (174 KB)
Molecules 2011, 16(11), 9261-9273; doi:10.3390/molecules16119261
Received: 28 September 2011; in revised form: 23 October 2011 / Accepted: 28 October 2011 / Published: 4 November 2011| Download PDF Full-text (412 KB)
Communication: Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block
Molecules 2011, 16(11), 9340-9356; doi:10.3390/molecules16119340
Received: 30 September 2011; in revised form: 19 October 2011 / Accepted: 21 October 2011 / Published: 7 November 2011| Download PDF Full-text (373 KB)
Review: Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade
Molecules 2012, 17(1), 1074-1102; doi:10.3390/molecules17011074
Received: 9 December 2011; in revised form: 11 January 2012 / Accepted: 12 January 2012 / Published: 20 January 2012| Download PDF Full-text (964 KB)
Article: Prebiotic Activity of Polysaccharides Extracted from Gigantochloa Levis (Buluh beting) Shoots
Molecules 2012, 17(2), 1635-1651; doi:10.3390/molecules17021635
Received: 11 October 2011; in revised form: 28 December 2011 / Accepted: 13 January 2012 / Published: 7 February 2012| Download PDF Full-text (424 KB)
Molecules 2012, 17(2), 1675-1685; doi:10.3390/molecules17021675
Received: 5 January 2012; in revised form: 20 January 2012 / Accepted: 29 January 2012 / Published: 8 February 2012| Download PDF Full-text (259 KB) |
Article: One-Pot Ugi/Aza-Michael Synthesis of Highly Substituted 2,5-Diketopiperazines with Anti-Proliferative Properties
Molecules 2012, 17(12), 14685-14699; doi:10.3390/molecules171214685
Received: 21 November 2012; in revised form: 1 December 2012 / Accepted: 6 December 2012 / Published: 11 December 2012| Download PDF Full-text (333 KB) |
Last update: 4 February 2013