Special Issue "Multicomponent Reaction"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 December 2012)

Special Issue Editor

Guest Editor
Dr. Irini Akritopoulou-Zanze
Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA
E-Mail: irini.zanze@abbott.com
Interests: drug discovery; de novo design and synthesis of biologically active scaffolds; focused compound libraries; multicomponent reactions

Special Issue Information

Dear Colleagues,

Multicomponent reactions (MCRs) are powerful transformations that incorporate portions of three or more reactants into new products in one pot procedures. They have been used extensively to form heterocyclic structures and they have been combined with subsequent transformations to yield complex structures, not easily accessible via classical synthetic reactions.
Efforts to discover new MCRs or further develop older ones, especially in combination with other transformations, contribute significantly to the advancement of organic synthesis by providing greater flexibility, novelty and efficiency. Applications of MCRs in drug discovery, material sciences, natural product synthesis and ligand and biological probe preparations further demonstrate the power of these reactions. Advances in cheminformatic tools allow for virtual MCR libraries to be first accessed in silico against a variety of different parameters before initiation of compound library synthesis.

This special issue of Molecules welcomes previously unpublished manuscripts covering all aspects of multicomponent reactions including their design, product assessment, methodology development and applications.

Dr. Irini Akritopoulou-Zanze
Guest Editor

Keywords

  • multicomponent reactions
  • isocyanide-based MCRS
  • heterocycle forming MCRS
  • library design
  • library synthesis
  • parallel synthesis
  • novel scaffolds
  • biologically active molecules
  • post MCR transformations
  • macromolecules

Published Papers (9 papers)

Molecules 2012, 17(12), 14685-14699; doi:10.3390/molecules171214685
Received: 21 November 2012; in revised form: 1 December 2012 / Accepted: 6 December 2012 / Published: 11 December 2012
Show/Hide Abstract | Download PDF Full-text (333 KB) |  Supplementary Files
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Molecules 2012, 17(2), 1675-1685; doi:10.3390/molecules17021675
Received: 5 January 2012; in revised form: 20 January 2012 / Accepted: 29 January 2012 / Published: 8 February 2012
Show/Hide Abstract | Download PDF Full-text (259 KB) |  Supplementary Files
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Molecules 2012, 17(2), 1635-1651; doi:10.3390/molecules17021635
Received: 11 October 2011; in revised form: 28 December 2011 / Accepted: 13 January 2012 / Published: 7 February 2012
Show/Hide Abstract | Download PDF Full-text (424 KB)

Molecules 2012, 17(1), 1074-1102; doi:10.3390/molecules17011074
Received: 9 December 2011; in revised form: 11 January 2012 / Accepted: 12 January 2012 / Published: 20 January 2012
Show/Hide Abstract | Download PDF Full-text (964 KB)
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Molecules 2011, 16(11), 9340-9356; doi:10.3390/molecules16119340
Received: 30 September 2011; in revised form: 19 October 2011 / Accepted: 21 October 2011 / Published: 7 November 2011
Show/Hide Abstract | Download PDF Full-text (373 KB)
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Molecules 2011, 16(11), 9261-9273; doi:10.3390/molecules16119261
Received: 28 September 2011; in revised form: 23 October 2011 / Accepted: 28 October 2011 / Published: 4 November 2011
Show/Hide Abstract | Download PDF Full-text (412 KB)

Molecules 2011, 16(11), 9161-9177; doi:10.3390/molecules16119161
Received: 13 September 2011; in revised form: 18 October 2011 / Accepted: 21 October 2011 / Published: 2 November 2011
Show/Hide Abstract | Download PDF Full-text (174 KB)

Molecules 2011, 16(10), 8815-8832; doi:10.3390/molecules16108815
Received: 17 August 2011; in revised form: 11 October 2011 / Accepted: 12 October 2011 / Published: 20 October 2011
Show/Hide Abstract | Download PDF Full-text (343 KB)

Molecules 2011, 16(10), 8775-8787; doi:10.3390/molecules16108775
Received: 21 September 2011; in revised form: 3 October 2011 / Accepted: 11 October 2011 / Published: 19 October 2011
Show/Hide Abstract | Download PDF Full-text (237 KB)
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Last update: 4 March 2014

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