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Molecules 2012, 17(1), 1074-1102; doi:10.3390/molecules17011074

Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade

Department Chemie, Technische Universität München, Lichtenbergstr. 4, Garching 85747, Germany
Received: 9 December 2011 / Revised: 11 January 2012 / Accepted: 12 January 2012 / Published: 20 January 2012
(This article belongs to the Special Issue Multicomponent Reaction)
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Abstract

A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS). These will provide a high degree of applying economical and ecological advantages as well as of practicability. Water, ionic liquids, and solvent-less syntheses as well as use of various forms of energy as microwave and ultrasonic irradiation are examined and discussed.
Keywords: multicomponent reaction; MCR; MFCR; I-MCR; isocyanide; heterocycle; diversity oriented synthesis; solvent-less synthesis; alternative energy; microwave multicomponent reaction; MCR; MFCR; I-MCR; isocyanide; heterocycle; diversity oriented synthesis; solvent-less synthesis; alternative energy; microwave
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Eckert, H. Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade. Molecules 2012, 17, 1074-1102.

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