Molecules 2011, 16(11), 9340-9356; doi:10.3390/molecules16119340
Communication

Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block

Received: 30 September 2011; in revised form: 19 October 2011 / Accepted: 21 October 2011 / Published: 7 November 2011
(This article belongs to the Special Issue Multicomponent Reaction)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C rapidly furnishes the title compounds in a one-pot fashion.
Keywords: alkyne; cyclocondensation; multi-component reaction; pyrazole; Sonogashira coupling
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MDPI and ACS Style

Levi, L.; Boersch, C.; Gers, C.F.; Merkul, E.; Müller, T.J.J. Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block. Molecules 2011, 16, 9340-9356.

AMA Style

Levi L, Boersch C, Gers CF, Merkul E, Müller TJJ. Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block. Molecules. 2011; 16(11):9340-9356.

Chicago/Turabian Style

Levi, Lucilla; Boersch, Christina; Gers, Charlotte F.; Merkul, Eugen; Müller, Thomas J. J. 2011. "Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block." Molecules 16, no. 11: 9340-9356.

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