Molecules 2011, 16(11), 9340-9356; doi:10.3390/molecules16119340
Communication

Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block

Lucilla Levi, Christina Boersch, Charlotte F. Gers, Eugen Merkul and Thomas J. J. Müller* email
Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, D-40225 Düsseldorf, Germany
* Author to whom correspondence should be addressed.
Received: 30 September 2011; in revised form: 19 October 2011 / Accepted: 21 October 2011 / Published: 7 November 2011
(This article belongs to the Special Issue Multicomponent Reaction)
PDF Full-text Download PDF Full-Text [373 KB, uploaded 7 November 2011 15:37 CET]
Abstract: A novel consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C rapidly furnishes the title compounds in a one-pot fashion.
Keywords: alkyne; cyclocondensation; multi-component reaction; pyrazole; Sonogashira coupling

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Levi, L.; Boersch, C.; Gers, C.F.; Merkul, E.; Müller, T.J.J. Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block. Molecules 2011, 16, 9340-9356.

AMA Style

Levi L, Boersch C, Gers CF, Merkul E, Müller TJJ. Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block. Molecules. 2011; 16(11):9340-9356.

Chicago/Turabian Style

Levi, Lucilla; Boersch, Christina; Gers, Charlotte F.; Merkul, Eugen; Müller, Thomas J. J. 2011. "Consecutive Three-Component Synthesis of 3-(Hetero)Aryl-1H-pyrazoles with Propynal Diethylacetal as a Three-Carbon Building Block." Molecules 16, no. 11: 9340-9356.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert