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Special Issue "Synthesis, Study and Utilization of Natural Products"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 15 March 2019

Special Issue Editors

Guest Editor
Prof. Dr. Pavel B. Drasar

Department of Chemistry of Natural Compounds, University of Chemistry and Technology, Prague, Technicka 5, CZ 166 28, Czech Republic
Website | E-Mail
Phone: +420 220 443 698
Interests: natural products chemistry; synthesis of heterocycles; non-hormonally active steroids; terpenes; supramolecular systems with chiral natural products; fluorescent labelling
Guest Editor
Prof. Dr. Vladimir A. Khripach

The Institute of Bioorganic Chemistry, The National Academy of Sciences of Belarus, 5/2 Academician V.F.Kuprevich Street, Minsk BY-220141, Republic of Belarus
Website | E-Mail
Interests: natural product heterocyclic and pesticide chemistry; synthesis, bioactivity and practical application of natural bioregulators and their analogs in agriculture and in medicine

Special Issue Information

Natural products are playing stable and growing roles in human and veterinary medicine, in food and the cosmetic industry and in other, increasing numbers of fields. Their importance is based i.a. on the fact that they are mostly bound to renewable sources, which in fact makes them valuable within a circular economy, i.a. However, natural products gave an origin of stereochemistry, regioselectivity, chirality, and many other features and disciplines within science, development, and industry in a scope which is indispensable.

This Special Issue aims to underline current developments in all fields that are connected to natural products.

Prof. Dr. Pavel B Drasar
Prof. Dr. Vladimir A Khripach
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products chemistry, biochemistry, repurposing, and practical utilization
  • synthesis of natural products
  • isolation and analysis of natural products
  • natural products in human and veterinary medicine
  • supramolecular systems with chiral natural products
  • fluorescent labelling, bioimiging
  • any topic with natural products not mentioned above

Published Papers (3 papers)

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Research

Open AccessArticle New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa
Molecules 2018, 23(7), 1723; https://doi.org/10.3390/molecules23071723
Received: 25 June 2018 / Revised: 10 July 2018 / Accepted: 11 July 2018 / Published: 14 July 2018
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Abstract
In this study, 19 octadecanoid derivatives—four pairs of enantiomers (18), two racemic/scalemic mixtures (910), and nine biosynthetically related analogues—were obtained from the ethanolic extract of a Chinese medicinal plant, Plantago depressa Willd. Their structures were
[...] Read more.
In this study, 19 octadecanoid derivatives—four pairs of enantiomers (18), two racemic/scalemic mixtures (910), and nine biosynthetically related analogues—were obtained from the ethanolic extract of a Chinese medicinal plant, Plantago depressa Willd. Their structures were elucidated on the basis of detailed spectroscopic analyses, with the absolute configurations of the new compounds assigned by time-dependent density functional theory (TD-DFT)-based electronic circular dichroism (ECD) calculations. Six of them (1, 36, and 9) were reported for the first time, while 2, 7, and 8 have been previously described as derivatives and are currently obtained as natural products. Our bioassays have established that selective compounds show in vitro anti-inflammatory activity by inhibiting lipopolysaccharide-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells. Full article
(This article belongs to the Special Issue Synthesis, Study and Utilization of Natural Products)
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Graphical abstract

Open AccessArticle Biosynthesis of Fluorescent β Subunits of C-Phycocyanin from Spirulina subsalsa in Escherichia coli, and Their Antioxidant Properties
Molecules 2018, 23(6), 1369; https://doi.org/10.3390/molecules23061369
Received: 29 April 2018 / Revised: 30 May 2018 / Accepted: 4 June 2018 / Published: 6 June 2018
PDF Full-text (2568 KB) | HTML Full-text | XML Full-text
Abstract
Phycocyanin, which covalently binds phycocyanobilin chromophores, is not only a candidate fluorescent probe for biological imaging, but also a potential antioxidative agent for healthcare. Herein, a plasmid harboring two cassettes was constructed, with cpcB from Spirulina subsalsa in one cassette and the fusion
[...] Read more.
Phycocyanin, which covalently binds phycocyanobilin chromophores, is not only a candidate fluorescent probe for biological imaging, but also a potential antioxidative agent for healthcare. Herein, a plasmid harboring two cassettes was constructed, with cpcB from Spirulina subsalsa in one cassette and the fusion gene cpcS::ho1::pcyA in the other, and then expressed in Escherichia coli. PCB-CpcB(C-82), a fluorescent phycocyanin β subunit, was biosynthesized in E. coli, exhibiting an absorption maximum at 620 nm and fluorescence emission maximum at 640 nm. When cpcS was replaced by cpcT, PCB-CpcB(C-153), another fluorescent phycocyanin β subunit, was produced, exhibiting an absorption maximum at 590 nm and fluorescence emission maximum at 620 nm. These two fluorescent biliproteins showed stronger scavenging activity toward hydroxyl and DPPH free radicals than apo-CpcB. The IC50 values for hydroxyl radical scavenging by PCB-CpcB(C-82), PCB-CpcB(C-153), and apo-CpcB were 38.72 ± 2.48 µg/mL, 51.06 ± 6.74 µg/mL, and 81.82 ± 0.67 µg/mL, respectively, and the values for DPPH radical scavenging were 201.00 ± 5.86 µg/mL, 240.34 ± 4.03 µg/mL, and 352.93 ± 26.30 µg/mL, respectively. The comparative antioxidant capacities of the proteins were PCB-CpcB(C-82) > PCB-CpcB(C-153) > apo-CpcB, due to bilin binding. The two fluorescent biliproteins exhibited a significant effect on relieving the growth of E. coli cells injured by H2O2. The results of this study suggest that the fluorescent phycocyanin β subunits of S. subsalsa were reconstructed by one expression vector in E. coli, and could be developed as potential antioxidants. Full article
(This article belongs to the Special Issue Synthesis, Study and Utilization of Natural Products)
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Figure 1

Open AccessArticle Synthesis of the Sex Pheromone of the Tea Tussock Moth Based on a Resource Chemistry Strategy
Molecules 2018, 23(6), 1347; https://doi.org/10.3390/molecules23061347
Received: 16 May 2018 / Revised: 30 May 2018 / Accepted: 3 June 2018 / Published: 4 June 2018
PDF Full-text (1562 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Synthesis of the sex pheromone of the tea tussock moth in 33% overall yield over 10 steps was achieved. Moreover, the chiral pool concept was applied in the asymmetric synthesis. The synthesis used a chemical available on a large-scale from recycling of wastewater
[...] Read more.
Synthesis of the sex pheromone of the tea tussock moth in 33% overall yield over 10 steps was achieved. Moreover, the chiral pool concept was applied in the asymmetric synthesis. The synthesis used a chemical available on a large-scale from recycling of wastewater from the steroid industry. The carbon skeleton was constructed using the C4+C5+C8 strategy. Based on this strategy, the original chiral center was totally retained. Full article
(This article belongs to the Special Issue Synthesis, Study and Utilization of Natural Products)
Figures

Graphical abstract

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