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Special Issue "Expanding the Potential of Metabolomics for Under Investigated Organisms and in Drug Discovery"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (31 March 2017)

Special Issue Editors

Guest Editor
Prof. Mohamed A. Farag

Faculty of Pharmacy, Department of Pharmacognosy, Cairo University, Cairo, Egypt
Website | E-Mail
Interests: metabolomics; herbal drugs quanlity control; NMR; MS; metabonomics
Guest Editor
Dr. Andrea Porzel

Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Germany
Website | E-Mail
Interests: NMR; phytochemistry; structural elucidation; metabolomics

Special Issue Information

Dear Colleagues,

Natural products (NPs) constitute an important part of our everyday diet; their components and nutritional/medicinal values have also been intensively studied for decades. The existence of NPs at minor levels in such a complex matrix, or being even labile, is expected, and isolation of such compounds still poses a challenge. The comparison of metabolite composition of biological systems (known as metabolomics) is now a mature field that has been increasingly applied to expedite natural products drug discovery. Metabolomics underlying emerging spectroscopic and informatics technologies has indeed demonstrated potential towards shorter drug discovery leading to a paradigm shift in NPs research. Metabolomics is rapidly evolving, with many novel techniques becoming available, i.e., MS imaging, HR-MAS NMR. The convergence of metabolomics and NPs discovery has also been demonstrated much more often from natural terrestrial origin mostly in planta, with much less evidence from other resources. It is expected that algae, fungi, sponges, sea corals, gut microbiota, etc., have an enormous potential to act as providers for novel bioactive metabolites. The integration of metabolomics towards facilitating the discovery and chemistry of plant derived NPs, is expected to be revealed from other organisms. In light of these urging topics, Molecules is introducing a new Special Issue on “Metabolomics” and its applications. This Special Issue shall include two general themes: The first is to focus on diverse range of metabolomics applications, many of which to be related to investigations in under investigated organisms. The second shall provide reports on novel experimental technologies in metabolomics or developments needed for the analysis of labile NP classes.

Prof. Mohamed A. Farag
Dr. Andrea Porzel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • natural products
  • drug discovery
  • algae
  • gut microbes
  • fungi
  • pure shift NMR
  • HR-MAS NMR
  • hyperpolarization NMR
  • MS imaging
  • metabolites profiling
  • bioinformatics

Published Papers (2 papers)

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Research

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Open AccessArticle MALDI-MS Imaging of Urushiols in Poison Ivy Stem
Molecules 2017, 22(5), 711; doi:10.3390/molecules22050711
Received: 30 March 2017 / Revised: 24 April 2017 / Accepted: 26 April 2017 / Published: 29 April 2017
Cited by 2 | PDF Full-text (6757 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Urushiols are the allergenic components of Toxicodendron radicans (poison ivy) as well as other Toxicodendron species. They are alk-(en)-yl catechol derivatives with a 15- or 17-carbon side chain having different degrees of unsaturation. Although several methods have been developed for analysis of urushiols
[...] Read more.
Urushiols are the allergenic components of Toxicodendron radicans (poison ivy) as well as other Toxicodendron species. They are alk-(en)-yl catechol derivatives with a 15- or 17-carbon side chain having different degrees of unsaturation. Although several methods have been developed for analysis of urushiols in plant tissues, the in situ localization of the different urushiol congeners has not been reported. Here, we report on the first analysis of urushiols in poison ivy stems by matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI). Our results show that the urushiol congeners with 15-carbon side chains are mainly localized to the resin ducts, while those with 17-carbon side chains are widely distributed in cortex and vascular tissues. The presence of these urushiols in stem extracts of poison ivy seedlings was confirmed by GC-MS. These novel findings provide new insights into the spatial tissue distribution of urushiols that might be biosynthetically or functionally relevant. Full article
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Review

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Open AccessReview Insights into Penicillium brasilianum Secondary Metabolism and Its Biotechnological Potential
Molecules 2017, 22(6), 858; doi:10.3390/molecules22060858
Received: 29 March 2017 / Revised: 12 May 2017 / Accepted: 12 May 2017 / Published: 20 June 2017
PDF Full-text (6048 KB) | HTML Full-text | XML Full-text
Abstract
Over the past few years Penicillium brasilianum has been isolated from many different environmental sources as soil isolates, plant endophytes and onion pathogen. All investigated strains share a great ability to produce bioactive secondary metabolites. Different authors have investigated this great capability and
[...] Read more.
Over the past few years Penicillium brasilianum has been isolated from many different environmental sources as soil isolates, plant endophytes and onion pathogen. All investigated strains share a great ability to produce bioactive secondary metabolites. Different authors have investigated this great capability and here we summarize the metabolic potential and the biological activities related to P. brasilianums metabolites with diverse structures. They include secondary metabolites of an alkaloid nature, i.e., 2,5-diketopiperazines, cyclodepsipeptides, meroterpenoids and polyketides. Penicillium brasilianum is also described as a great source of enzymes with biotechnological application potential, which is also highlighted in this review. Additionally, this review will focus on several aspects of Penicillium brasilianum and interesting genomic insights. Full article
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