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Special Issue "Liposomes as Drug Carriers"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 10 January 2018

Special Issue Editors

Guest Editor
Prof. Sophia G. Antimisiaris

Pharmaceutical Technology Laboratory, Department of Pharmacy, University of Patras, Rion 26510, Greece; and Institute of Chemical Engineering, FORTH/ICE-HT, Platani, Rio 26504, Greece
Website1 | Website2 | E-Mail
Interests: liposomes; nanoparticles; nanomedicines for drug delivery; targeting; controlled release; cellular vesicles; exosomes
Guest Editor
Dr. Spyridon Mourtas

Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Patras, Rio 26504, Greece
E-Mail
Interests: liposomes; nanoparticles; functionalization; targeting; organic chemistry; peptide synthesis

Special Issue Information

Dear Colleagues,

Liposomes are broadly used as nanocarriers for controlled delivery/ targeting of drugs. Indeed, liposomal formulations may have an important impact on the therapeutic potential of active substances, just by providing the means to protect them from hostile environments in the biological milieu, and/or by increasing their retention at sites of administration or action, increasing, thus, their topical bioavailability.

Furthermore, due to their exceptional physicochemical characteristics, including their small size (at nanoscale), biological compatibility, versatility (which allows easy surface modification) and capability to encapsulate/incorporate high amounts of almost any type of active molecule, they are on the top of the list when challenging drug delivery applications are under consideration. Examples of the later include early diagnosis and/or therapy of neurodegenerative diseases (Alzheimer’s disease, Parkinson’s, Amyotrophic lateral sclerosis (ALS), Multiple sclerosis (MS), etc.), were delivery of drugs to the brain is impeded by the blood brain barrier; as well as realization of the therapeutic potential of oligonucleotides, were the physicochemical properties of the actives and their substantial susceptibility to degrading enzymes are major obstacles. A number of technologies which enable surface modification of liposomes (using different types of ligands, such as peptides, antibodies, small organic molecules, aptamers, etc.), by gentle organic-synthesis protocols, have led to the formation of actively- targeted functionalized vesicles with increased affinity for specific biological targets or barriers. The exploitation of biological approaches to overcome barriers, such as those used by bacteria and viruses, and more recently the organotropism of extracellular vesicles, have also been considered for the construction of bio-inspired liposomes, with increased targeting capability. This Special Issue is aimed at covering all the different approaches of liposome diagnostic/therapeutic applications, with specific examples from recent projects.

Prof. Sophia G. Antimisiaris
Dr. Spyridon Mourtas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liposomes
  • nanocarriers
  • controlled release
  • retention
  • bioavailability
  • active targeting
  • surface modification
  • exosomes
  • cellular vesicles

Published Papers

This special issue is now open for submission.
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