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Extraction, Assessment and Function Mechanism of Bioactivities from Natural Products...
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Extraction, Assessment and Function Mechanism of Bioactivities from Natural Products and Microorganism Metabolites

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6223

Special Issue Editors

Prof. Dr. Rina Wu

E-Mail Website
Guest Editor
College of Food Science, Shenyang Agricultural University, Shenyang 110866, China
Interests: microbiology; probiotics and prebiotics; functional food; flora micbiotia; fermentation; homology of medicine and food
Prof. Dr. Peng Wang

grade E-Mail Website
Guest Editor
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
Interests: meat protein; meat quality; molecular assembly; bioavailability
Special Issues, Collections and Topics in MDPI journals
Dr. Liang Zhao

E-Mail Website
Guest Editor
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100107, China
Interests: lactic acid bacteria; prebiotics; gut microbiota; lipid metabolism; NAFLD
Dr. Wei Wang

E-Mail Website
Guest Editor
Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, China
Interests: biologically active peptides; natural food ingredients; mechanism of functional components; functional oils
Prof. Dr. Haitian Fang

E-Mail Website
Guest Editor
Ningxia Key Laboratory for Food Microbial-Applications Technology and Safety Control, School of Agriculture, Ningxia University, Yinchuan, Ningxia, 750021, China
Interests: food biomanufacturing; microbiology and metabolic engineering; probiotics and prebiotics; fermentation; microbial resources

Special Issue Information

Dear Colleagues,

With the in-depth research on natural food ingredients and probiotic metabolites, the developments of extraction and evaluation technology are key progress steps in the field of functional ingredients research. Different extraction methods affect not only the degree of loss of functional components, but also the active strength of the extract. By apposite assessment methods, the optimal extraction process can be obtained, and the biological activity mechanism of the extract, such as antioxidants, anti-inflammatory, lipid-lowering, etc., can be effectively explored. Therefore, the journal focuses on obtaining new bioactive components from natural products or microorganism, or extraction and evaluation the bioactive components by new methods or auxiliary extraction methods, and explores the function mechanism of the isolated functional components. We hope to develop a comprehensive understanding of bioactive components from different sources and their functional activities for the development of bioactive substances that integrate extraction, evaluation, and action mechanism.

Prof. Dr. Rina Wu
Prof. Dr. Peng Wang
Dr. Liang Zhao
Dr. Wei Wang
Prof. Dr. Haitian Fang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extraction technology
  • extraction efficiency
  • antioxidant capacities
  • natural products
  • microorganism metabolites
  • assisted extraction
  • identification
  • stability
  • evaluation assay

Published Papers (3 papers)

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Research

18 pages, 3054 KiB  
Article
Postbiotics Derived from L. paracasei ET-22 Inhibit the Formation of S. mutans Biofilms and Bioactive Substances: An Analysis
by Zhi Zhao, Jianmin Wu, Zhe Sun, Jinbo Fan, Fudong Liu, Wen Zhao, Wei-Hsien Liu, Ming Zhang and Wei-Lian Hung
Molecules 2023, 28(3), 1236; https://doi.org/10.3390/molecules28031236 - 27 Jan 2023
Cited by 5 | Viewed by 2178
Abstract
Globally, dental caries is one of the most common non-communicable diseases for patients of all ages; Streptococcus mutans (S. mutans) is its principal pathogen. Lactobacillus paracasei (L. paracasei) shows excellent anti-pathogens and immune-regulation functions in the host. The aim [...] Read more.
Globally, dental caries is one of the most common non-communicable diseases for patients of all ages; Streptococcus mutans (S. mutans) is its principal pathogen. Lactobacillus paracasei (L. paracasei) shows excellent anti-pathogens and immune-regulation functions in the host. The aim of this study is to evaluate the effects of L. paracasei ET-22 on the formation of S. mutans biofilms. The living bacteria, heat-killed bacteria, and secretions of L. paracasei ET-22 were prepared using the same number of bacteria. In vitro, they were added into artificial-saliva medium, and used to coculture with the S. mutans. Results showed that the living bacteria and secretions of L. paracasei ET-22 inhibited biofilm-growth, the synthesis of water-soluble polysaccharide and water-insoluble polysaccharide, and virulence-gene-expression levels related to the formation of S. mutans biofilms. Surprisingly, the heat-killed L. paracasei ET-22, which is a postbiotic, also showed a similar regulation function. Non-targeted metabonomics technology was used to identify multiple potential active-substances in the postbiotics of L. paracasei ET-22 that inhibit the formation of S. mutans biofilms, including phenyllactic acid, zidovudine monophosphate, and citrulline. In conclusion, live bacteria and its postbiotics of L. paracasei ET-22 all have inhibitory effects on the formation of S. mutans biofilm. The postbiotics of L. paracasei ET-22 may be a promising biological anticariogenic-agent. Full article
(This article belongs to the Special Issue Extraction, Assessment and Function Mechanism of Bioactivities from Natural Products and Microorganism Metabolites)
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12 pages, 3627 KiB  
Article
Napyradiomycin A4 and Its Relate Compounds, a New Anti-PRV Agent and Their Antibacterial Activities, from Streptomyces kebangsaanensis WS-68302
by Yani Zhang, Wei Fang, Kaimei Wang, Zhigang Zhang, Zhaoyuan Wu, Liqiao Shi, Fang Liu, Zhongyi Wan and Manli Liu
Molecules 2023, 28(2), 640; https://doi.org/10.3390/molecules28020640 - 8 Jan 2023
Cited by 3 | Viewed by 1463
Abstract
Two new napyradiomycins derivatives, napyradiomycin A4 (1) and A80915 H (2), along with five known ones, were isolated from the ethyl acetate extract of fermentation culture of Streptomyces kebangsaanensis WS-68302. Their structures were elucidated by extensive spectroscopic analysis, including [...] Read more.
Two new napyradiomycins derivatives, napyradiomycin A4 (1) and A80915 H (2), along with five known ones, were isolated from the ethyl acetate extract of fermentation culture of Streptomyces kebangsaanensis WS-68302. Their structures were elucidated by extensive spectroscopic analysis, including HR-MS, 1D and 2D NMR, CD spectrum, as well as comparison with literature data. Compound 1 exhibited significant antiviral activity against PRV (Pseudorabies virus) with an IC50 value of 2.056 μM and therapeutic ratio at 14.98, suggesting that it might have potential for development of an antiviral agent. Moreover, compound 1 displayed the strongest inhibition against PRV protein among the tested napyradiomycins in the indirect immunofuorescence assay. Compounds 3 and 4 showed higher activities against swine pathogenic Streptococcus suis than the positive control penicillin G sodium salt, with MIC values of 3.125 and 6.25 μg/mL, respectively. Compounds 1 and 3–6 exhibited moderate antibacterial activity against the swine pathogenic Erysipelothrix rhusiopathiae, with MIC values ranging from 25 to 50 μg/mL. Full article
(This article belongs to the Special Issue Extraction, Assessment and Function Mechanism of Bioactivities from Natural Products and Microorganism Metabolites)
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15 pages, 2717 KiB  
Article
Isolation of a New Polysaccharide from Dandelion Leaves and Evaluation of Its Antioxidant, Antibacterial, and Anticancer Activities
by Mo Li, Henan Zhang, Xinyu Hu, Yumeng Liu, Yanfeng Liu, Meijun Song, Rina Wu and Junrui Wu
Molecules 2022, 27(21), 7641; https://doi.org/10.3390/molecules27217641 - 7 Nov 2022
Cited by 7 | Viewed by 2008
Abstract
Dandelion, in China, has a long history as a medicinal and edible plant, and possesses high nutritional and medical value. The present study aimed to isolate a new polysaccharide (DLP-3) from dandelion leaves and to evaluate its antioxidant, antibacterial, and anticancer activities. The [...] Read more.
Dandelion, in China, has a long history as a medicinal and edible plant, and possesses high nutritional and medical value. The present study aimed to isolate a new polysaccharide (DLP-3) from dandelion leaves and to evaluate its antioxidant, antibacterial, and anticancer activities. The structure of DLP-3 was analyzed using HPLC, FT-IR, SEM, GC-MS, and NMR spectroscopy. DLP-3 mainly consisted of Man, Rha, GlcA, Glc, Gal, and Ara with molar ratios of 2.32, 0.87, 1.21, 3.84, 1.00, and 1.05, respectively, with a molecular weight of 43.2 kDa. The main linkages of DLP-3 contained (1→4)-α-d-Glc, (1→4,6)-α-d-Glc, (1→6)-α-d-Gal, (1→2)-α-d-Man, (1→4)-α-d-Man, β-l-Ara-(1→, and α-l-Rha-(1→. DLP-3 exhibited a smooth surface, purely flake-like structure, and a triple helix conformation. Moreover, DLP-3 presented obvious antioxidant and antibacterial activities in a concentration-dependent manner. DLP-3 showed significant anticancer activities by inhibiting tumor cell proliferation. These findings provide a theoretical basis for the application of DLP-3 as a natural functional active substance in functional foods. Full article
(This article belongs to the Special Issue Extraction, Assessment and Function Mechanism of Bioactivities from Natural Products and Microorganism Metabolites)
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