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Managing Editor Dr. Shu-Kun Lin MDPI, St. Alban-Anlage 66, CH-4052 Basel, Switzerland Website \| E-Mail Interests: Gibbs paradox; entropy; symmetry; similarity; diversity; information theory; thermodynamics; process irreversibility or spontaneity; stability; nature of the chemical processes; molecular recognition; open access journals
Editorial Advisor Prof. Dr. Naozumi Teramoto Department of Applied Chemistry, Faculty of Engineering, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba 275-0016, Japan Website \| E-Mail Fax: +81 47 478 0406 Interests: biomaterial; bio-based polymer; bioplastics; biodegradable polymer; biopolymer; composite material comprising a polymer matrix

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Open AccessReview Design and Applications of Biodegradable Polyester Tissue Scaffolds Based on Endogenous Monomers Found in Human Metabolism

by Devin G. Barrett and Muhammad N. Yousaf

Molecules 2009, 14(10), 4022-4050; doi:10.3390/molecules14104022

Received: 19 August 2009 / Revised: 22 September 2009 / Accepted: 28 September 2009 / Published: 12 October 2009

Cited by 56 | PDF Full-text (739 KB) | Supplementary Files

Abstract

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Synthetic polyesters have deeply impacted various biomedical and engineering fields, such as tissue scaffolding and therapeutic delivery. Currently, many applications involving polyesters are being explored with polymers derived from monomers that are endogenous to the human metabolism. Examples of these monomers include glycerol, xylitol, sorbitol, and lactic, sebacic, citric, succinic, α-ketoglutaric, and fumaric acids. In terms of mechanical versatility, crystallinity, hydrophobicity, and biocompatibility, polyesters synthesized partially or completely from these monomers can display a wide range of properties. The flexibility in these macromolecular properties allows for materials to be tailored according to the needs of a particular application. Along with the presence of natural monomers that allows for a high probability of biocompatibility, there is also an added benefit that this class of polyesters is more environmentally friendly than many other materials used in biomedical engineering. While the selection of monomers may be limited by nature, these polymers have produced or have the potential to produce an enormous number of successes in vitro and in vivo. Full article

(This article belongs to the Special Issue Biodegradation: Organic, Medicinal and Analytical Chemistry)

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Special Issue "Biodegradation: Organic, Medicinal and Analytical Chemistry"

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