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Special Issue "Lectins: From Basic Science to Application for Glycobiology, Cell Biology, and Medicine"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: 28 February 2018

Special Issue Editors

Guest Editor
Prof. Dr. Tomohisa Ogawa

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan
Website | E-Mail
Interests: lectins; protein science; molecular evolution; lectin-carbohydrate interaction; venomics
Guest Editor
Dr. Hiroaki Tateno

Department of Life Science and Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan
Website | E-Mail
Interests: lectins; glycans, stem cells; regenerative medicine; drug discovery; diagnosis; exosome; cancer stem cells

Special Issue Information

Dear Colleagues,

It is our great pleasure to inform you that a Special Issue on “Lectins: From Basic Science to Application for Glycobiology, Cell Biology, and Medicine” will be published in the journal Molecules. Lectins are carbohydrate-binding proteins, which recognize the specific carbohydrate structures expressed on cells and mediate various physiological and pathological phenomenon through cell-cell and host-pathogen communications. Lectins are useful as research tools for glycomic analysis, and cell identification/separation. They were also demonstrated to be applied as cargo to deliver drugs inside cells, such as stem cells and tumor cells.

In this Special Issue, we focused on lectins from basics to applications for glycobiology, cell biology, and medicine.

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • lectin
  • carbohydrate
  • glycome
  • cell recognition

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Expression of Pinellia ternate Lectin Gene in Transgenic Wheat and its Resistance Analysis against Wheat Aphids
Authors: Duan XiaoLiang, Pang Xiaomeng, Liu Guoyu, Wang Xiao, Niu Zhenli, Zhang Yufeng, Li Baoyun, Liang Rongqi*
Affiliation: (Key Laboratory of Crop Heterosis and Utilization (MOE)/Beijing Key Laboratory of Crop Genetic Improvement, College of Agronomy, China Agricultural University, Beijing, 100193)
Corresponding Author: Rongqi Liang, E-mail: liangrq@cau.edu.cn
Abstract: Wheat aphids are the major pests during the seed filling stage of wheat. Plant lectins have been shown to be toxic to sap-sucking pest such as wheat aphids. In this study, pta (Pinellia ternate agglutinin) gene encoding mannose binding lectin was cloned, and driven by constitutive and phloem-specific rbcs promoter in the expression vector. The pta gene was transferred into the wheat cultivar Baofeng104 by particle bombardment transformation. After selected by BASTA and differentiation, fifty-four T0 transgenic plants were generated. The integration and transcription of the pta gene were confirmed by PCR and RT-PCR analysis respectively, and seven transgenic lines were obtained. Aphid bioassay on detached leaf segments revealed that seven pta transgenic wheat lines had lower aphid growth rate and higher aphid mortality than Baofeng104. Furthermore, two-year aphid bioassays in isolated field showed that aphids numbers per tiller of transgenic lines were decreased significantly, compared with wildtype Baofeng104. Therefore, pta could be a strong biotechnological candidate for use in efforts to produce aphid-resistant wheat.
Keywords: Pinellia ternate agglutinin (pta); Lectin; Transgenic wheat; Wheat aphid; Aphid resistance

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