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Special Issue "Selected Papers from the 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017)"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (15 October 2017)

Special Issue Editors

Guest Editor
Assoc. Prof. Dr. Angeles Heras Caballero

Associate professor and presently Head of Dept. at Department of Pharmaceutical Physical-Chemistry, Faculty of Pharmacy, University of Madrid (UCM). Infiqus promoter, Spain
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Interests: chitin; chitosan; functional characterization; natural products; chitosan applications (food, cosmetic, pharmaceutic, biomedical)
Guest Editor
Assoc. Prof. Dr. Francisca Cabrera-Escribano

Department of Organic Chemistry, Faculty of Chemistry, University of Seville, Seville, Spain
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Interests: chitosan; carbohydrate chemistry; fluorescent heteroaromatic systems; sensing biomaterials; glycoaminoacids; organic synthesis; noncovalent interactions; heterogeneous organocatalysis
Guest Editor
Dr. Inmaculada Aranaz Corral

Researcher at Department of Pharmaceutical Physical-Chemistry, Faculty of Pharmacy, Complutense University of Madrid (UCM), Spain
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Interests: natural polymers (chitin, chitosan, alginates); chitosan derivatives; functional characterization; synthetic polymers; green processes; polymer networks; biomaterials; drug delivery
Guest Editor
Dr. Florentina Niuris Acosta Contreras

Associate Professor. Department of Pharmaceutical Physical-Chemistry, Faculty of Pharmacy. Complutense University of Madrid (UCM), Spain. InFiQuS R&D supervisor, Spain
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Interests: biopolymers; chitosan derivatives; physico chemical and functional characterization; green processes; polymer networks; biomaterials; drug delivery; pharmaceutical formulation

Special Issue Information

Dear Colleagues,

The 13th International Conference of the European Chitin Society – 8th Simposio de la Sociedad Iberoamericana de Quitina (EUCHIS-SIAQ 2017)—will be jointly held from 31 May to 3 June, 2017, in Seville, Spain, at the Faculty of Chemistry, located at the Reina Mercedes Science Campus of the University of Seville.

Supported by a strong international advisory board, we have designed the conference as a meeting point for young, junior and senior researchers, producers and developers of chitin/chitosan-based products from all over the word. The program of EUCHIS-SIAQ 2017 Congress aims at fostering communication between our Scientific Societies and between Science and Industry. The conference will offer a wide interdisciplinary exchange at the forefront of chitin/chitosan science with a strong presence of suppliers, manufacturers and end-users companies. A specific session with information on funding opportunities for researchers, companies and research-company consortium will be also held. The conference will be preceded by an Industrial Meeting to face up the Industry challenges that will be held in Madrid, and followed by the second edition of the Young Research Meeting to be held in Seville. Excellent speakers will present their results within individual sections of EUCHIS-SIAQ 2017. For all details please see http://www.chitin2017.com, where the full list of presenters is available, including Caroline Hoemann, Laurent David, Alessandro Gandini, Hermenegildo García, and many others.

Participants of the Conference are cordially invited to contribute original research papers or reviews to this Special Issue of Molecules.

Assoc. Prof. Dr Angeles Heras Caballero (A. Heras)
Assoc. Prof. Dr. Francisca Cabrera-Escribano (F. Cabrera-Escribano)
Ph.D. Inmaculada Aranaz Corral (I. Aranaz)
Ph.D. Florentina Niuris Acosta Contreras (N. Acosta)
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle Electrostatic Self-Assembled Chitosan-Pectin Nano- and Microparticles for Insulin Delivery
Molecules 2017, 22(10), 1707; doi:10.3390/molecules22101707
Received: 14 July 2017 / Revised: 29 September 2017 / Accepted: 4 October 2017 / Published: 12 October 2017
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Abstract
A polyelectrolyte complex system of chitosan-pectin nano- and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to obtain small particles for oral insulin delivery without chemical crosslinkers based on natural and biodegradable polysaccharides. The nano- and microparticles
[...] Read more.
A polyelectrolyte complex system of chitosan-pectin nano- and microparticles was developed to encapsulate the hormone insulin. The aim of this work was to obtain small particles for oral insulin delivery without chemical crosslinkers based on natural and biodegradable polysaccharides. The nano- and microparticles were developed using chitosans (with different degrees of acetylation: 15.0% and 28.8%) and pectin solutions at various charge ratios (n+/n given by the chitosan/pectin mass ratio) and total charge. Nano- and microparticles were characterized regarding particle size, zeta potential, production yield, encapsulation efficiency, stability in different media, transmission electron microscopy and cytotoxicity assays using Caco-2 cells. The insulin release was evaluated in vitro in simulated gastric and intestinal media. Small-sized particles (~240–~1900 nm) with a maximum production yield of ~34.0% were obtained. The highest encapsulation efficiency (~62.0%) of the system was observed at a charge ratio (n+/n) 5.00. The system was stable in various media, particularly in simulated gastric fluid (pH 1.2). Transmission electron microscopy (TEM) analysis showed spherical shape particles when insulin was added to the system. In simulated intestinal fluid (pH 6.8), controlled insulin release occurred over 2 h. In vitro tests indicated that the proposed system presents potential as a drug delivery for oral administration of bioactive peptides. Full article
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