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Special Issue "Design and Synthesis of Quorum-Sensing Inhibitors"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: closed (15 October 2017)

Special Issue Editor

Guest Editor
Prof. Dr. Naresh Kumar

School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia
Website | E-Mail
Interests: quorum sensing inhibitors; antimicrobial biomaterials; antimicrobial peptides and mimics; RNAP-σ factor inhibitors; dual-action antimicrobials

Special Issue Information

Dear Colleagues,

With the long-term overuse and misuse of antibiotics, the problem of antibiotic-resistance is now reaching a critical stage. Antibiotics are no longer the magic bullets they were once thought to be and therefore there is an urgent need for development of alternative therapeutic strategies to combat infections without inducing drug resistance. Quorum-sensing (QS) inhibition presents a promising alternative strategy, since it attenuates bacterial virulence by disrupting the signaling pathway between bacteria without inducing stress.

Several strategies to combat this problem are discussed:

i)     Isolation of natural products with quorum sensing (QS) inhibitory activities and developing their synthetic analogues;
ii)    Synthesis of new classes of QSI with anti-virulence and anti-biofilm properties;
iii)   Rational design of QSIs;
iv)   Structure-activity relationship studies of QSIs;
v)    Applications and targeted delivery of QSIs;
vi)   Dual-action and hybrid QSIs;
vii)  Synergistic activities of QSIs.

Molecules will publish a Special Issue focusing on the “Design and Synthesis of Quorum-Sensing Inhibitors”, as well as novel molecular targets with reduced capacity to develop antibiotic resistance. It is my pleasure to invite submissions of high quality research-based papers related to the topics mentioned above.

Prof. Naresh Kumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


• Discovery of new classes of quorum sensing inhibitors
• Synthesis of quorum sensing inhibitors with antimicrobial activity
• Rational design of quorum sensing inhibitors
• Development of methods for the targeted delivery of quorum sensing inhibitors

Published Papers

This special issue is now open for submission.
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