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Special Issue "Chirality in Health and Environment: Recent developments"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Synthesis".

Deadline for manuscript submissions: 31 December 2017

Special Issue Editors

Guest Editor
Prof. Dr. Madalena M. M. Pinto

Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências, Químicas, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira 228, 4050-313, Porto, Portugal; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
Website | E-Mail
Interests: medicinal chemistry; drug discovery and drug design; synthesis and bioenantioselectivity studies of chiral bioactive compounds, as well as studies of structure-activity and structure-properties relationships; molecular recognition-artificial receptors as new chiral stationary phases for HPLC
Guest Editor
Assist. Prof. Carla Fernandes

CIIMAR and Laboratório de Química Orgânica e Farmacêutica, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
Website | E-Mail
Interests: design and synthesis of chiral compounds with potential biological activity as well as chiral stationary phases for liquid chromatography; analytical and preparative enantiomeric separation of racemic mixtures and studies of chiral recognition mechanisms

Special Issue Information

Dear Colleagues,

It is well known that the environment and human health are directly connected in many ways, with chirality interrelating both areas; why is this?

Human beings, as well as many biological molecules, are chiral, including numerous natural products and several substances created by man, interacting with the environment.

Life on Earth, as we know it, depends on chiral molecules, and the recent discovery of an astronomical chiral molecule, propylene oxide, representative of the earliest stage of solar system evolution, makes us believe that, as far as the subject matter of chirality is concerned, “the sky is the limit”!

This progress results of several inter/transdisciplinary fields from, among others, physics, chemistry and biology, which are very challenging for researchers involved in these areas.

This Special Issue is intended to highlight and update the state-of-the-art and recent progress in several topics, namely:

  • Chirality in daily life: Chemical communication among humans; importance of odor (flavors and fragrances; perception of chiral odorants) and taste (artificial sweeteners); chiral cosmetics and personal care products.
  • Chirality in chemical and pharmaceutical industries.
  • Chiral drugs/pharmaceuticals.
  • Chirality of molecules from nature.
  • Chiral xenobiotics in marine and terrestrial ecosystems.
  • Chiral analysis.

Prof. Madalena Pinto
Assist. Prof. Carla Fernandes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Chirality
  • Chiral molecules
  • Health
  • Environment

Published Papers (1 paper)

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Research

Open AccessArticle Enantiomeric-Enriched Ferrocenes: Synthesis, Chiral Resolution, and Mathematic Evaluation of CD-chiral Selector Energies with Ferrocene-Conjugates
Molecules 2017, 22(9), 1410; doi:10.3390/molecules22091410
Received: 14 July 2017 / Revised: 23 August 2017 / Accepted: 24 August 2017 / Published: 25 August 2017
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Abstract
Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH3 (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes. X-ray structural data for racemic (R,S)-1N-(3,5-dimethyl
[...] Read more.
Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH3 (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes. X-ray structural data for racemic (R,S)-1N-(3,5-dimethyl pyrazolyl)ethyl ferrocene (1) and its (S)-enantiomer (S)-1 were determined. A series of racemic pyrazolylalkyl ferrocenes was separated into enantiomers by analytical HPLC on β- and γ-cyclodextrins (CD) chiral stationary phases. The quantum chemical calculations of interaction energies of β-CD were carried out for both (R)- and (S)-enantiomers. A high correlation between experimental HPLC data and calculated interaction energies values was obtained. Full article
(This article belongs to the Special Issue Chirality in Health and Environment: Recent developments)
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