Novel Anticancer Therapies Targeting Stem Cells

Dear Colleagues,

The therapeutic effectiveness of conventional anticancer modalities has been limited by undesirable side effects, resistance to treatment, and cancer recurrence. These therapeutic strategies eliminate the highly proliferative cells forming the tumor bulk but fail to eradicate the sub-population of self-renewing cancer stem cells (CSCs). The CSCs that escape treatment can develop resistance and give rise to diverse tumor populations, resulting in cancer recurrence. Over the past decade, there has been growing interest in developing therapeutic approaches to eliminate these CSCs. Great efforts have been made to identify naturally derived or synthetic therapeutic agents that can target specific signaling pathways or cell surface biomarkers of CSCs in addition to delivering non-coding RNA to restore target gene expression. In recent years, combination cancer therapy has attracted considerable attention given its potential to simultaneously modulate multiple targets to intensify the therapeutic outcome against CSCs.

This Special Issue focuses on new trends in the development of therapeutic strategies to target CSCs. You are invited to submit original research articles and reviews relevant to this topic.

Prof. Dr. Hala Gali-Muhtasib
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• cancer stem cells
• chemoresistance
• gene therapy
• targeted therapy
• combination therapy
• natural products