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Special Issue "Herbal Remedies Meet Modern Day Medicine: Challenges and Opportunities"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 10 July 2017

Special Issue Editor

Guest Editor
Prof. Dr. Hala Gali-Muhtasib

Department of Biology and Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Lebanon
Website | E-Mail
Interests: cancer; anticancer; herbal medicine; drug delivery; cell death mechanisms

Special Issue Information

Dear Colleagues,

For a long time, herbal medicine has been prepared, synthesized, and used as therapeutics, based on generations of indigenous practices. The upsurge of herbal remedies today has been largely driven by public demand, and billions of dollars are spent annually on herbal medications. The response of the healthcare sector to this issue has been varied: Some reject it because of unidentified toxicological repercussions, while others believe we need to be open-minded, yet critical, about the use of herbal medicines. It is important to document the effectiveness of herbal medicines, their potential adverse side effects, and drug–drug interactions with orthodox pharmaceuticals. We are all responsible to promote both the rational and safe use of folk herbals remedies, and we are responsible for the consequences. This Special Issue aims to highlight evidence-based research on herbal medicines with an emphasis on all aspects, including legal, medical, research, and economic aspects, in order to tackle challenges associated with herbal remedies and to provide greater opportunities for their future use.

Prof. Dr. Hala Gali-Muhtasib
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • herbal remedies
  • folk medicines
  • safety and toxicity
  • evidence-based research
  • policies on herbal medicine
  • drug-drug interactions
  • side effects of herbals

Published Papers (2 papers)

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Research

Open AccessArticle Gubenyiliu II Inhibits Breast Tumor Growth and Metastasis Associated with Decreased Heparanase Expression and Phosphorylation of ERK and AKT Pathways
Molecules 2017, 22(5), 787; doi:10.3390/molecules22050787
Received: 2 April 2017 / Revised: 7 May 2017 / Accepted: 8 May 2017 / Published: 15 May 2017
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Abstract
Gubenyiliu II (GYII), a Traditional Chinese Medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients. In this study, we investigated the molecular mechanisms underlying the beneficial effects of GYII on murine breast cancer models. GYII showed significant inhibitory
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Gubenyiliu II (GYII), a Traditional Chinese Medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients. In this study, we investigated the molecular mechanisms underlying the beneficial effects of GYII on murine breast cancer models. GYII showed significant inhibitory effects on tumor growth and metastasis in the murine breast cancer model. Additionally, GYII suppressed the proliferation of 4T1 and MCF-7 cells in a dose-dependent manner. A better inhibitory effect on 4T1 cell proliferation and migration was found in the decomposed recipes (DR) of GYII. Moreover, heparanase expression and the degree of angiogenesis were reduced in tumor tissues. Western blot analysis showed decreased expression of heparanase and growth factors in the cells treated with GYII and its decomposed recipes (DR2 and DR3), and thereby a reduction in the phosphorylation of extracellular signal-regulated kinase (ERK) and serine-threonine kinase (AKT). These results suggest that GYII exerts anti-tumor growth and anti-metastatic effects in the murine breast cancer model. The anti-tumor activity of GYII and its decomposed recipes is, at least partly, associated with decreased heparanase and growth factor expression, which subsequently suppressed the activation of the ERK and AKT pathways. Full article
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Open AccessArticle A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines
Molecules 2017, 22(4), 632; doi:10.3390/molecules22040632
Received: 2 March 2017 / Revised: 6 April 2017 / Accepted: 12 April 2017 / Published: 14 April 2017
PDF Full-text (1636 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Herbal medicines are widely used for treating liver diseases and generally regarded as safe due to their extensive use in Traditional Chinese Medicine practice for thousands of years. However, in recent years, there have been increased concerns regarding the long-term risk of Herb-Induced
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Herbal medicines are widely used for treating liver diseases and generally regarded as safe due to their extensive use in Traditional Chinese Medicine practice for thousands of years. However, in recent years, there have been increased concerns regarding the long-term risk of Herb-Induced Liver Injury (HILI) in patients with liver dysfunction. Herein, two representative Chinese herbal medicines: one—Xiao-Chai-Hu-Tang (XCHT)—a composite formula, and the other—Radix Polygoni Multiflori (Heshouwu)—a single herb, were analyzed by network pharmacology study. Based on the network pharmacology framework, we exploited the potential HILI effects of XCHT and Heshouwu by predicting the molecular mechanisms of HILI and identified the potential hepatotoxic ingredients in XCHT and Heshouwu. According to our network results, kaempferol and thymol in XCHT and rhein in Heshouwu exhibit the largest number of liver injury target connections, whereby CASP3, PPARG and MCL1 may be potential liver injury targets for these herbal medicines. This network pharmacology assay might serve as a useful tool to explore the underlying molecular mechanism of HILI. Based on the theoretical predictions, further experimental verification should be performed to validate the accuracy of the predicted interactions between herbal ingredients and protein targets in the future. Full article
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