Special Issue "Microfluidic Devices for High-Throughput Screening"

A special issue of Micromachines (ISSN 2072-666X).

Deadline for manuscript submissions: 31 December 2017

Special Issue Editor

Guest Editor
Prof. Dr. Liang Dong

Department of Electrical and Computer Engineering, Iowa State University, Ames, IA 50011, USA
Website1 | Website2 | E-Mail
Phone: +1-515-294-0388
Fax: +1-515-294-8432
Interests: MEMS; lab on a chip; microfluidics; sensors; microoptics and nanophotonics

Special Issue Information

Dear Colleagues,

Microfluidic technology has provided powerful high-throughput screening platforms to simultaneously perform a large number of chemical, genetic, or pharmacological tests, thus allowing rapid identification of chemical compounds, antibodies, and genes responsible for modulation of a particular biomolecular pathway. Many microfluidic devices have shown great potential to aid drug discovery and target validation, and expedite functional genomics and phenomics studies. In particular, some devices have already started to provide researchers and even pharmaceutical industry with an increasing number of molecular targets for therapeutic intervention, thus having increasing academic, social and economic impacts. This Special Issue seeks to contribute to this emergent field by featuring research papers, communications, opinion papers, and review articles from methodological and disciplinary perspectives, focusing on microfluidic devices enabled high throughput assays for biological, chemical, and environmental conditions of single cells and multicellular organisms. Of particular interest is the focus on system automation and miniaturization towards high-throughput approaches to gaining deeper insight into the effects and functions of molecules and the correlation between genomic and phenomic variables.

Prof. Dr. Liang Dong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • microfluidics
  • lab on a chip
  • high throughput screening
  • single cells studies
  • multicellular organisms

Published Papers (1 paper)

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Research

Open AccessArticle Numerical Investigation of a Novel Wiring Scheme Enabling Simple and Accurate Impedance Cytometry
Micromachines 2017, 8(9), 283; doi:10.3390/mi8090283
Received: 13 August 2017 / Revised: 6 September 2017 / Accepted: 12 September 2017 / Published: 18 September 2017
Cited by 1 | PDF Full-text (4688 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Microfluidic impedance cytometry is a label-free approach for high-throughput analysis of particles and cells. It is based on the characterization of the dielectric properties of single particles as they flow through a microchannel with integrated electrodes. However, the measured signal depends not only
[...] Read more.
Microfluidic impedance cytometry is a label-free approach for high-throughput analysis of particles and cells. It is based on the characterization of the dielectric properties of single particles as they flow through a microchannel with integrated electrodes. However, the measured signal depends not only on the intrinsic particle properties, but also on the particle trajectory through the measuring region, thus challenging the resolution and accuracy of the technique. In this work we show via simulation that this issue can be overcome without resorting to particle focusing, by means of a straightforward modification of the wiring scheme for the most typical and widely used microfluidic impedance chip. Full article
(This article belongs to the Special Issue Microfluidic Devices for High-Throughput Screening)
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