Special Issue "Scaffold Materials for Tissue Engineering"
Deadline for manuscript submissions: 31 August 2018
Prof. Dr. Jose M.F. Ferreira
Department of Materials and Ceramics Engineering, CICECO, University of Aveiro, Campus Santiago, 3810-193 Aveiro, Portugal
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Interests: osteoinductive materials; additive manufacturing of 3D porous scaffolds; customer made orthopedic implants; bioprinting of cellularized constructs; tissue decellularization as a strategy to obtain specific extracellular matrix (ECM) scaffolds for engineering tissues/organs
Research efforts are often driven by real needs for new or better materials, processes or systems that do not satisfactorily fulfil expected/desired roles or functions. The discovery of bioactive glasses (BGs) in the late 1960s, intended to replace inert metal and plastic implants that were not well tolerated by the body, represents a remarkable milestone in the field of synthetic and resorbable bone grafts. This discovery has inspired many other investigations, aiming at further exploring the in vitro and in vivo performances of BGs and other inorganic bioactive materials based on calcium phosphates and or inorganic/organic composites by suitably mixing the inorganic components with biopolymer matrices aiming at better mimicking the mechanical behavior and properties of bone tissues. However, successful tissue engineering strategies typically involve a combination of cells and bioactive factors with an implantable porous biomaterial construct to provide an environment conducive to cell differentiation and proliferation. Several processing techniques might be used to generate the 3D porous structure. Printing methods have recently gained tremendous importance, being increasingly applied to inorganic, polymeric and composite acellular materials. However, some of the most exciting developments in the last years are related to: (i) the bioprinting of cellularized constructs from hydrogels to engineer heterogeneously cellular 3D environments that lead to tissues that can mimic specific organ functions; and (ii) multifunctional devices that include in situ drug release and antibacterial activity. Contributions to this Special Issue on the abovementioned topics, but not limited to them, will be welcome.
Prof. Dr. Jose M.F. Ferreira
Manuscript Submission Information
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- bioactive bone graft materials
- osteoinduction of hMSC
- porous constructs
- additive manufacturing techniques