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Materials 2018, 11(9), 1580; https://doi.org/10.3390/ma11091580

Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold

1
Image Diagnostic Service, Virgen de la Arrixaca University Hospital, UCAM-Universidad Catolica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain
2
Preclinical Imaging Unit, Laboratory Animal Service, University of Murcia, 30107 Murcia, Spain
3
Tissue Regeneration and Repair Group: Orthobiology, Biomaterials and Tissue Engineering, UCAM-San Antonio Catholic University of Murcia, Guadalupe, 30107 Murcia, Spain
4
Pathology Unit, IMIB-Arrixaca, 30120 El Palmar (Murcia), Spain
5
Orthopaedic and Trauma Service, Virgen de la Arrixaca University Hospital, El Palmar, 30120 Murcia, Spain
6
Department of Orthopaedic Surgery and Trauma, School of Medicine, Lab of Regeneration and Tissue Repair, UCAM-Universidad Catolica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain
7
Instituto de Bioingeniería, Universidad Miguel Hernández-UMH, Avda. Ferrocarril s/n. Elche, 03202 Alicante, Spain
*
Author to whom correspondence should be addressed.
Received: 17 July 2018 / Revised: 28 July 2018 / Accepted: 26 August 2018 / Published: 1 September 2018
(This article belongs to the Special Issue Scaffold Materials for Tissue Engineering)
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Abstract

The aim of this study was to manufacture and evaluate the effect of a biphasic calcium silicophosphate (CSP) scaffold ceramic, coated with a natural demineralized bone matrix (DBM), to evaluate the efficiency of this novel ceramic material in bone regeneration. The DBM-coated CSP ceramic was made by coating a CSP scaffold with gel DBM, produced by the partial sintering of different-sized porous granules. These scaffolds were used to reconstruct defects in rabbit tibiae, where CSP scaffolds acted as the control material. Micro-CT and histological analyses were performed to evaluate new bone formation at 1, 3, and 5 months post-surgery. The present research results showed a correlation among the data obtained by micro-CT and the histomorphological results, the gradual disintegration of the biomaterial, and the presence of free scaffold fragments dispersed inside the medullary cavity occupied by hematopoietic bone marrow over the 5-month study period. No difference was found between the DBM-coated and uncoated implants. The new bone tissue inside the implants increased with implantation time. Slightly less new bone formation was observed in the DBM-coated samples, but it was not statistically significant. Both the DBM-coated and the CSP scaffolds gave excellent bone tissue responses and good osteoconductivity. View Full-Text
Keywords: dicalcium silicate; tricalcium phosphate; demineralized bone matrix; bone regeneration; micro-CT; histomorphometry dicalcium silicate; tricalcium phosphate; demineralized bone matrix; bone regeneration; micro-CT; histomorphometry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Parrilla-Almansa, A.; García-Carrillo, N.; Ros-Tárraga, P.; Martínez, C.M.; Martínez-Martínez, F.; Meseguer-Olmo, L.; De Aza, P.N. Demineralized Bone Matrix Coating Si-Ca-P Ceramic Does Not Improve the Osseointegration of the Scaffold. Materials 2018, 11, 1580.

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