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Nanoprobes for Imaging
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Nanoprobes for Imaging

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (1 February 2017) | Viewed by 21144

Special Issue Editor

Prof. Dr. Zeev Zalevsky

E-Mail Website
Guest Editor
Faculty of Engineering, Bar Ilan University, Ramat Gan 529002, Israel
Interests: optical super resolution; biomedical optics; nano-photonics and electro-optical devices

Special Issue Information

Dear Colleagues,

Currently, the usage of nanoprobes and nanoparticles (NP) is increasing significantly as they are integrated into various fields of research and technology involving medical treatment, such as drug delivery or ablation and photo thermal therapy, or for sensing and imaging.

In this Special Issue, we aim to collect cutting-edge scientific papers dealing with the fabrication, syntheses of the NPs, as well as their usage and implementation in various fields of optical imaging, including microscopy and nanoscopy, super resolution, fluorescent imaging, photoacoustic imaging, and molecular imaging. We also wish to receive papers involving usage of NPs in sensors, in which those nanostructures, e.g., yield surface enhanced effects, such as surface enhanced Raman scattering and surface enhanced fluorescence.

Prof. Dr. Zeev Zalevsky
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Super resolution
  • fluorescent imaging
  • photoacoustic imaging
  • molecular imaging

Published Papers (4 papers)

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Research

9338 KiB  
Article
Haemocompatibility of Modified Nanodiamonds
by Michał Wąsowicz, Mateusz Ficek, Maciej S. Wróbel, Ruchira Chakraborty, Dror Fixler, Paweł Wierzba and Małgorzata Jędrzejewska-Szczerska
Materials 2017, 10(4), 352; https://doi.org/10.3390/ma10040352 - 28 Mar 2017
Cited by 35 | Viewed by 5125
Abstract
This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human [...] Read more.
This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along with spectral measurements and determination of haemolysis. The results showed that no more than 3% of cells were affected by the nanodiamonds. Specific modifications of the nanodiamonds give us the possibility to obtain nanoparticles which are biocompatible with human blood. They can form a basis for the development of nanoscale biomarkers and parts of sensing systems and devices useful in biomedical environments. Full article
(This article belongs to the Special Issue Nanoprobes for Imaging)
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3183 KiB  
Article
Improved Margins Detection of Regions Enriched with Gold Nanoparticles inside Biological Phantom
by Yossef Danan, Inbar Yariv, Zeev Zalevsky and Moshe Sinvani
Materials 2017, 10(2), 203; https://doi.org/10.3390/ma10020203 - 20 Feb 2017
Cited by 8 | Viewed by 4009
Abstract
Utilizing the surface plasmon resonance (SPR) effect of gold nanoparticles (GNPs) enables their use as contrast agents in a variety of biomedical applications for diagnostics and treatment. These applications use both the very strong scattering and absorption properties of the GNPs due to [...] Read more.
Utilizing the surface plasmon resonance (SPR) effect of gold nanoparticles (GNPs) enables their use as contrast agents in a variety of biomedical applications for diagnostics and treatment. These applications use both the very strong scattering and absorption properties of the GNPs due to their SPR effects. Most imaging methods use the light-scattering properties of the GNPs. However, the illumination source is in the same wavelength of the GNPs’ scattering wavelength, leading to background noise caused by light scattering from the tissue. In this paper we present a method to improve border detection of regions enriched with GNPs aiming for the real-time application of complete tumor resection by utilizing the absorption of specially targeted GNPs using photothermal imaging. Phantoms containing different concentrations of GNPs were irradiated with a continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. By modulating the laser illumination, and use of a simple post processing, the border location was identified at an accuracy of better than 0.5 mm even when the surrounding area got heated. This work is a continuation of our previous research. Full article
(This article belongs to the Special Issue Nanoprobes for Imaging)
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2671 KiB  
Article
Targeted Magnetic Nanoparticles for Mechanical Lysis of Tumor Cells by Low-Amplitude Alternating Magnetic Field
by Adi Vegerhof, Eran A. Barnoy, Menachem Motiei, Dror Malka, Yossef Danan, Zeev Zalevsky and Rachela Popovtzer
Materials 2016, 9(11), 943; https://doi.org/10.3390/ma9110943 - 22 Nov 2016
Cited by 21 | Viewed by 6464
Abstract
Currently available cancer therapies can cause damage to healthy tissue. We developed a unique method for specific mechanical lysis of cancer cells using superparamagnetic iron oxide nanoparticle rotation under a weak alternating magnetic field. Iron oxide core nanoparticles were coated with cetuximab, an [...] Read more.
Currently available cancer therapies can cause damage to healthy tissue. We developed a unique method for specific mechanical lysis of cancer cells using superparamagnetic iron oxide nanoparticle rotation under a weak alternating magnetic field. Iron oxide core nanoparticles were coated with cetuximab, an anti-epidermal growth factor receptor antibody, for specific tumor targeting. Nude mice bearing a head and neck tumor were treated with cetuximab-coated magnetic nanoparticles (MNPs) and then received a 30 min treatment with a weak external alternating magnetic field (4 Hz) applied on alternating days (total of seven treatments, over 14 days). This treatment, compared to a pure antibody, exhibited a superior cell death effect over time. Furthermore, necrosis in the tumor site was detected by magnetic resonance (MR) images. Thermal camera images of head and neck squamous cell carcinoma cultures demonstrated that cell death occurred purely by a mechanical mechanism. Full article
(This article belongs to the Special Issue Nanoprobes for Imaging)
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5407 KiB  
Article
Tissue-Like Phantoms as a Platform for Inserted Fluorescence Nano-Probes
by Tsviya Nayhoz, Eran A. Barnoy and Dror Fixler
Materials 2016, 9(11), 926; https://doi.org/10.3390/ma9110926 - 15 Nov 2016
Cited by 7 | Viewed by 5113
Abstract
Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in [...] Read more.
Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents. Full article
(This article belongs to the Special Issue Nanoprobes for Imaging)
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