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Materials 2016, 9(11), 943; doi:10.3390/ma9110943

Targeted Magnetic Nanoparticles for Mechanical Lysis of Tumor Cells by Low-Amplitude Alternating Magnetic Field

1
Faculty of Engineering & The Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel
2
Faculty of Engineering Holon Institute of Technology, Holon 5810201, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Jordi Sort
Received: 5 September 2016 / Revised: 30 October 2016 / Accepted: 17 November 2016 / Published: 22 November 2016
(This article belongs to the Special Issue Nanoprobes for Imaging)
View Full-Text   |   Download PDF [2671 KB, uploaded 22 November 2016]   |  

Abstract

Currently available cancer therapies can cause damage to healthy tissue. We developed a unique method for specific mechanical lysis of cancer cells using superparamagnetic iron oxide nanoparticle rotation under a weak alternating magnetic field. Iron oxide core nanoparticles were coated with cetuximab, an anti-epidermal growth factor receptor antibody, for specific tumor targeting. Nude mice bearing a head and neck tumor were treated with cetuximab-coated magnetic nanoparticles (MNPs) and then received a 30 min treatment with a weak external alternating magnetic field (4 Hz) applied on alternating days (total of seven treatments, over 14 days). This treatment, compared to a pure antibody, exhibited a superior cell death effect over time. Furthermore, necrosis in the tumor site was detected by magnetic resonance (MR) images. Thermal camera images of head and neck squamous cell carcinoma cultures demonstrated that cell death occurred purely by a mechanical mechanism. View Full-Text
Keywords: biomedical; magnetic field; MRI; cetuximab; head and neck cancer biomedical; magnetic field; MRI; cetuximab; head and neck cancer
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Vegerhof, A.; Barnoy, E.A.; Motiei, M.; Malka, D.; Danan, Y.; Zalevsky, Z.; Popovtzer, R. Targeted Magnetic Nanoparticles for Mechanical Lysis of Tumor Cells by Low-Amplitude Alternating Magnetic Field. Materials 2016, 9, 943.

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