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Materials 2016, 9(11), 926; doi:10.3390/ma9110926

Tissue-Like Phantoms as a Platform for Inserted Fluorescence Nano-Probes

Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 5290002, Israel
Author to whom correspondence should be addressed.
Academic Editor: Zeev Zalevsky
Received: 19 September 2016 / Revised: 26 October 2016 / Accepted: 9 November 2016 / Published: 15 November 2016
(This article belongs to the Special Issue Nanoprobes for Imaging)
View Full-Text   |   Download PDF [5407 KB, uploaded 15 November 2016]   |  


Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated gold nanorods in solution, as well as inserted in solid tissue-imitating phantoms. A lack of consistency between the fluorescence lifetime results of the solutions and the phantoms raises a question about the ability of tissue-like phantoms to maintain the optical properties of inserted contrast agents. View Full-Text
Keywords: tissue-like phantoms; dual-modal imaging; fluorescence lifetime (FLT); FLT imaging (FLIM); diffusion reflection tissue-like phantoms; dual-modal imaging; fluorescence lifetime (FLT); FLT imaging (FLIM); diffusion reflection

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nayhoz, T.; Barnoy, E.A.; Fixler, D. Tissue-Like Phantoms as a Platform for Inserted Fluorescence Nano-Probes. Materials 2016, 9, 926.

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