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Materials 2017, 10(4), 352; doi:10.3390/ma10040352

Haemocompatibility of Modified Nanodiamonds

1
Department of Morphological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warszawa, Poland
2
Department of Metrology and Optoelectronics, Faculty of Electronics, Telecommunications and Informatics, Gdańsk University of Technology, Narutowicza 11/12, 80-233 Gdańsk, Poland
3
Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan 5290002, Israel
*
Author to whom correspondence should be addressed.
Academic Editor: Zeev Zalevsky
Received: 22 November 2016 / Revised: 21 March 2017 / Accepted: 23 March 2017 / Published: 28 March 2017
(This article belongs to the Special Issue Nanoprobes for Imaging)
View Full-Text   |   Download PDF [9338 KB, uploaded 28 March 2017]   |  

Abstract

This study reports the interactions of modified nanodiamond particles in vitro with human blood. Modifications performed on the nanodiamond particles include oxygenation with a chemical method and hydrogenation upon chemical vapor deposition (CVD) plasma treatment. Such nanodiamonds were later incubated in whole human blood for different time intervals, ranging from 5 min to 5 h. The morphology of red blood cells was assessed along with spectral measurements and determination of haemolysis. The results showed that no more than 3% of cells were affected by the nanodiamonds. Specific modifications of the nanodiamonds give us the possibility to obtain nanoparticles which are biocompatible with human blood. They can form a basis for the development of nanoscale biomarkers and parts of sensing systems and devices useful in biomedical environments. View Full-Text
Keywords: haemocompatibility; nanodiamonds; spectroscopy; blood; biophotonics haemocompatibility; nanodiamonds; spectroscopy; blood; biophotonics
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Wąsowicz, M.; Ficek, M.; Wróbel, M.S.; Chakraborty, R.; Fixler, D.; Wierzba, P.; Jędrzejewska-Szczerska, M. Haemocompatibility of Modified Nanodiamonds. Materials 2017, 10, 352.

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