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Materials 2017, 10(2), 203; doi:10.3390/ma10020203

Improved Margins Detection of Regions Enriched with Gold Nanoparticles inside Biological Phantom

Faculty of Engineering, Bar-Ilan University, Ramat-Gan 5290002, Israel
The Bar-Ilan Institute of Nanotechnology & Advanced Materials, Bar-Ilan University, Ramat-Gan 5290002, Israel
Author to whom correspondence should be addressed.
Academic Editor: Erik Reimhult
Received: 31 December 2016 / Revised: 12 February 2017 / Accepted: 14 February 2017 / Published: 20 February 2017
(This article belongs to the Special Issue Nanoprobes for Imaging)
View Full-Text   |   Download PDF [3183 KB, uploaded 20 February 2017]   |  


Utilizing the surface plasmon resonance (SPR) effect of gold nanoparticles (GNPs) enables their use as contrast agents in a variety of biomedical applications for diagnostics and treatment. These applications use both the very strong scattering and absorption properties of the GNPs due to their SPR effects. Most imaging methods use the light-scattering properties of the GNPs. However, the illumination source is in the same wavelength of the GNPs’ scattering wavelength, leading to background noise caused by light scattering from the tissue. In this paper we present a method to improve border detection of regions enriched with GNPs aiming for the real-time application of complete tumor resection by utilizing the absorption of specially targeted GNPs using photothermal imaging. Phantoms containing different concentrations of GNPs were irradiated with a continuous-wave laser and measured with a thermal imaging camera which detected the temperature field of the irradiated phantoms. By modulating the laser illumination, and use of a simple post processing, the border location was identified at an accuracy of better than 0.5 mm even when the surrounding area got heated. This work is a continuation of our previous research. View Full-Text
Keywords: surface plasmon resonance; gold nanorods; photothermal imaging; laser beam modulation surface plasmon resonance; gold nanorods; photothermal imaging; laser beam modulation

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Danan, Y.; Yariv, I.; Zalevsky, Z.; Sinvani, M. Improved Margins Detection of Regions Enriched with Gold Nanoparticles inside Biological Phantom. Materials 2017, 10, 203.

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