Special Issue "Synthesis around Marine Natural Products"

Guest Editor
Prof. Dr. Yoshihide Usami
Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
E-Mail:
Interests: natural product; anti-cancer; bioactive; structure determination; total synthesis; chemical modification

Submission

All papers should be submitted to marinedrugs@mdpi.org with copy to the Editors. To be published continuously until the deadline and papers will be listed together at the special websites. Both, research articles and review articles are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editors for announcment on this website.

Submitted papers should not have been published previously, nor be under consideration for publication elsewhere. All papers are refereed through a peer-review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed quarterly journal published by Molecular Diversity Preservation International.

Please visit the Instructions for Authors page before submitting a paper. Open Access publication fees are 1000 CHF per paper. English correction fees (250 CHF) will be added in certain cases (1250 CHF per paper for those papers that require extensive additional formatting and/or English corrections.).

• Marine natural product
• Bioactive
• Total synthesis
• Structural assignment
• Chemical transformation
• Chemical modification

Title: Generating a Generation of Proteasome Inhibitors: NPI-0052 and the Salinosporamides
Authors: Venkat R. Macherla, Kin S. Lam and Barbara C. Potts
Affiliation: Nereus Pharmaceuticals Inc., 10480 Wateridge Circle, San Diego, CA 92121 USA
Abstract: The salinosporamides are potent 20S proteasome inhibitors for which the parent marine-derived natural product (salinosporamide A; NPI-0052) is currently in clinical trials for the treatment of various cancers. Methods to generate this class of compounds include fermentation, semisynthesis, total synthesis and mutasynthesis, which have collectively enabled a detailed understanding of their mechanism of action at the molecular level and production of clinical trials materials. The full complement of techniques is reviewed, with an emphasis on chemical methods.