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Mar. Drugs 2009, 7(2), 249-257; doi:10.3390/md7020249

New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum

Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan
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Received: 18 May 2009 / Revised: 11 June 2009 / Accepted: 15 June 2009 / Published: 16 June 2009
(This article belongs to the Special Issue Synthesis around Marine Natural Products)
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Abstract

Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells. View Full-Text
Keywords: fungus; marine-fish; Chaetomium globosum; cytotoxicity; chaetomugilins; azaphilones; chemical transformation; alkaline degradation fungus; marine-fish; Chaetomium globosum; cytotoxicity; chaetomugilins; azaphilones; chemical transformation; alkaline degradation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yamada, T.; Muroga, Y.; Tanaka, R. New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum. Mar. Drugs 2009, 7, 249-257.

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