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Mar. Drugs 2009, 7(2), 249-257; doi:10.3390/md7020249
Article

New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum

* ,  and
Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan
* Author to whom correspondence should be addressed.
Received: 18 May 2009 / Revised: 11 June 2009 / Accepted: 15 June 2009 / Published: 16 June 2009
(This article belongs to the Special Issue Synthesis around Marine Natural Products)
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Abstract

Seco-chaetomugilins A and D were isolated from a strain of Chaetomium globosum that was originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, along with the chemical transformation from known chaetomugilins A and D. Seco-chaetomugilin D exhibited growth inhibitory activity against cultured P388, HL-60, L1210, and KB cells.
Keywords: fungus; marine-fish; Chaetomium globosum; cytotoxicity; chaetomugilins; azaphilones; chemical transformation; alkaline degradation fungus; marine-fish; Chaetomium globosum; cytotoxicity; chaetomugilins; azaphilones; chemical transformation; alkaline degradation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yamada, T.; Muroga, Y.; Tanaka, R. New Azaphilones, Seco-Chaetomugilins A and D, Produced by a Marine-Fish-Derived Chaetomium globosum. Mar. Drugs 2009, 7, 249-257.

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