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Mar. Drugs 2012, 10(2), 358-402; doi:10.3390/md10020358

Synthetic Strategies to Terpene Quinones/Hydroquinones

Farmacy Faculty and Institute of Science and Technology Studies, Campus Miguel de Unamuno, Salamanca University, 37007 Salamanca, Spain
Received: 26 December 2011 / Revised: 3 February 2012 / Accepted: 3 February 2012 / Published: 14 February 2012
(This article belongs to the Special Issue Synthesis around Marine Natural Products)


The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.
Keywords: terpene quinone; terpene hydroquinone; synthesis; chemical modification terpene quinone; terpene hydroquinone; synthesis; chemical modification
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gordaliza, M. Synthetic Strategies to Terpene Quinones/Hydroquinones. Mar. Drugs 2012, 10, 358-402.

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