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Mar. Drugs 2012, 10(2), 358-402; doi:10.3390/md10020358

Synthetic Strategies to Terpene Quinones/Hydroquinones

Farmacy Faculty and Institute of Science and Technology Studies, Campus Miguel de Unamuno, Salamanca University, 37007 Salamanca, Spain
Received: 26 December 2011 / Revised: 3 February 2012 / Accepted: 3 February 2012 / Published: 14 February 2012
(This article belongs to the Special Issue Synthesis around Marine Natural Products)


The cytotoxic and antiproliferative properties of many natural sesquiterpene-quinones and -hydroquinones from sponges offer promising opportunities for the development of new drugs. A review dealing with different strategies for obtaining bioactive terpenyl quinones/hydroquinones is presented. The different synthetic approches for the preparation of the most relevant quinones/hydroquinones are described.
Keywords: terpene quinone; terpene hydroquinone; synthesis; chemical modification terpene quinone; terpene hydroquinone; synthesis; chemical modification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gordaliza, M. Synthetic Strategies to Terpene Quinones/Hydroquinones. Mar. Drugs 2012, 10, 358-402.

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