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Mar. Drugs 2010, 8(3), 483-497; doi:10.3390/md8030483
Review

Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa

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Received: 21 January 2010; in revised form: 2 March 2010 / Accepted: 2 March 2010 / Published: 5 March 2010
(This article belongs to the Special Issue Synthesis around Marine Natural Products)
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Abstract: 3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this article we report the syntheses of these secondary metabolites from Haliclona viscosa and related compounds and give a short overview of the bioactivity.
Keywords: 3-alkyl pyridinium alkaloids; Haliclona viscosa; synthesis; marine natural products 3-alkyl pyridinium alkaloids; Haliclona viscosa; synthesis; marine natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Timm, C.; Mordhorst, T.; Köck, M. Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa. Mar. Drugs 2010, 8, 483-497.

AMA Style

Timm C, Mordhorst T, Köck M. Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa. Marine Drugs. 2010; 8(3):483-497.

Chicago/Turabian Style

Timm, Christoph; Mordhorst, Thorsten; Köck, Matthias. 2010. "Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa." Mar. Drugs 8, no. 3: 483-497.



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