Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa

doi:10.3390/md8030483

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Mar. Drugs 2010, 8(3), 483-497; doi:10.3390/md8030483

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Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa

Christoph Timm, Thorsten Mordhorst and Matthias Köck

Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570 Bremerhaven, Germany

* Author to whom correspondence should be addressed.

Received: 21 January 2010; in revised form: 2 March 2010 / Accepted: 2 March 2010 / Published: 5 March 2010

(This article belongs to the Special Issue Synthesis around Marine Natural Products)

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Abstract: 3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C–F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this article we report the syntheses of these secondary metabolites from Haliclona viscosa and related compounds and give a short overview of the bioactivity.

Keywords: 3-alkyl pyridinium alkaloids; Haliclona viscosa; synthesis; marine natural products

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MDPI and ACS Style

Timm, C.; Mordhorst, T.; Köck, M. Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa. Mar. Drugs 2010, 8, 483-497.

AMA Style

Timm C, Mordhorst T, Köck M. Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa. Marine Drugs. 2010; 8(3):483-497.

Chicago/Turabian Style

Timm, Christoph; Mordhorst, Thorsten; Köck, Matthias. 2010. "Synthesis of 3-Alkyl Pyridinium Alkaloids from the Arctic Sponge Haliclona viscosa." Mar. Drugs 8, no. 3: 483-497.

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