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• Pauletti, P
• Cintra, L
• Braguine, C
• Filho, A
• Silva, M
• Cunha, W
• Januário, A
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• Pauletti, P
• Cintra, L
• Braguine, C
• Filho, A
• Silva, M
• Cunha, W
• Januário, A
• [+] on PubMed
• Pauletti, P
• Cintra, L
• Braguine, C
• Filho, A
• Silva, M
• Cunha, W
• Januário, A

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Mar. Drugs 2010, 8(5), 1526-1549; doi:10.3390/md8051526

Review

Halogenated Indole Alkaloids from Marine Invertebrates

Patrícia Mendonça Pauletti, Lucas Silva Cintra, Caio Guedes Braguine, Ademar Alves da Silva Filho, Márcio Luís Andrade e Silva, Wilson Roberto Cunha*  and Ana Helena Januário*

Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca. Av. Dr. Armando Salles de Oliveira, 201, CEP 14404-600, Franca, São Paulo, Brazil

* Authors to whom correspondence should be addressed.

Received: 2 March 2010; in revised form: 19 April 2010 / Accepted: 23 April 2010 / Published: 28 April 2010

(This article belongs to the Special Issue Bioactive Halogenated Metabolites of Marine Origin)

Download PDF Full-Text [349 KB, uploaded 28 April 2010 12:07 CEST]

Abstract: This review discusses the isolation, structural elucidation, and biological activities of halogenated indole alkaloids obtained from marine invertebrates. Meridianins and related compounds (variolins, psammopemmins, and aplicyanins), as well as aplysinopsins and leptoclinidamines, are focused on. A compilation of the ¹³C-NMR spectral data of these selected natural indole alkaloids is also provided.

Keywords: marine invertebrates; halogenated indole alkaloids; structure elucidation; bioactivity; ¹³C-NMR spectral data

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