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Mar. Drugs 2010, 8(6), 1743-1749; doi:10.3390/md8061743

Antibacterial Activities of a New Brominated Diterpene from Borneon Laurencia spp.

1
Laboratory of Natural Products Chemistry, Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, 88999 Kota Kinabalu, Sabah, Malaysia
2
Shimadzu (Asia Pacific) Pte Ltd, 16 Science Park Drive, #01-01, The Pasteur Singapore Science Park, 118227, Singapore
*
Author to whom correspondence should be addressed.
Received: 4 May 2010 / Accepted: 14 May 2010 / Published: 26 May 2010
(This article belongs to the Special Issue Bioactive Halogenated Metabolites of Marine Origin)
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Abstract

In our continuous interest to study the diversity of halogenated metabolites of Malaysian species of the red algal genus Laurencia, we examined the chemical composition of five populations of unrecorded Laurencia sp. A new brominated diterpene, 10-acetoxyangasiol (1), and four other known metabolites, aplysidiol (2), cupalaurenol (3), 1-methyl-2,3,5-tribromoindole (4), and chamigrane epoxide (5), were isolated and identified. Isolated metabolites exhibited potent antibacterial activities against clinical bacteria, Staphylococcus aureus, Staphylococcus sp., Streptococcus pyogenes, Salmonella sp. and Vibrio cholerae.
Keywords: Laurencia sp.; halogenated metabolites; antibacterial activity Laurencia sp.; halogenated metabolites; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Vairappan, C.S.; Ishii, T.; Lee, T.K.; Suzuki, M.; Zhaoqi, Z. Antibacterial Activities of a New Brominated Diterpene from Borneon Laurencia spp.. Mar. Drugs 2010, 8, 1743-1749.

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