Special Issue "Mechanisms of Toxicity of Dioxins and Related Compounds"
Deadline for manuscript submissions: closed (15 April 2014)
Dr. Raimo Pohjanvirta
Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 66, FI-00014 University of Helsinki, Finland
Interests: dioxins; AH receptor; estrogenic and genotoxic chemicals in foodstuffs
Dioxins have been subject to extensive research activity for the past half a century. It has become clear that these compounds are ubiquitous and persistent environmental contaminants, and that the group encompasses congeners with exceptionally high toxic potency, as exemplified by the model compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
The elucidation of the canonical AH receptor (AHR) signaling in the 1970s and 80s was a major breakthrough in our understanding of dioxin toxicity mechanisms. The present view is that an inappropriately intense and/or protracted activation of this signal transduction system constitutes the basis of most, if not all, major toxicities elicited by dioxins. However, the pathogenetic processes following AHR activation that eventually culminate in the well-described manifestations of dioxin exposure in laboratory animals have largely remained elusive – even to the extent that the critical target tissue for the acute toxicity of TCDD has yet to be established.
On the other hand, progress has been made in some subfields. In the last decade, the increasing interest of the scientific community in AHR’s physiological functions has simultaneously helped advance the elucidation of dioxin action mechanisms. This is because TCDD has been one of the most common AHR activators employed. TCDD has also been exploited as a potent pharmacological tool in studies aimed at shedding light on insufficiently understood physiological or pathological phenomena. Consequently, novel information has been gained on the interference of dioxins with the immune system (e.g., autoimmune reactions), reproductive organs, and liver functions (steatohepatitis).
A Special Issue devoted to dioxin toxicity mechanisms in the International Journal of Molecular Sciences is thus timely and well-grounded. All manuscripts furthering our current understanding on how dioxins impart their adverse health effects are welcome, be they based on in vivo or in vitro experiments. Of particular interest would be studies on impacts mediated by alternative, non-canonical signaling pathways, or by epigenetic mechanisms. As mentioned above, there is still a notable data gap of biochemical steps between AHR-mediated gene regulation and toxic signs. At the cellular or tissue level, some intriguing topics would be the effects of dioxins on stem cells and on the central nervous system. Mechanistic explanations for the wide differences in sensitivities to dioxin toxicity, both among and within species, are further called for. More information is also needed on the mechanisms of dioxin carcinogenicity.
Dr. Raimo Pohjanvirta
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- aryl hydrocarbon receptor
- AH receptor
- persistent organic pollutants
- toxicity mechanisms
- transcription factors
- bHLH/PAS proteins
Review: Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls
Int. J. Mol. Sci. 2014, 15(8), 14044-14057; doi:10.3390/ijms150814044
Received: 13 May 2014; in revised form: 8 July 2014 / Accepted: 16 July 2014 / Published: 13 August 2014| PDF Full-text (1429 KB)
Article: Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Hormones of Energy Balance in a TCDD-Sensitive and a TCDD-Resistant Rat Strain
Int. J. Mol. Sci. 2014, 15(8), 13938-13966; doi:10.3390/ijms150813938
Received: 14 May 2014; in revised form: 24 July 2014 / Accepted: 29 July 2014 / Published: 12 August 2014| PDF Full-text (3273 KB)
Article: Epigenetic Determinants of CYP1A1 Induction by the Aryl Hydrocarbon Receptor Agonist 3,3',4,4',5-Pentachlorobiphenyl (PCB 126)
Int. J. Mol. Sci. 2014, 15(8), 13916-13931; doi:10.3390/ijms150813916
Received: 4 June 2014; in revised form: 6 August 2014 / Accepted: 7 August 2014 / Published: 11 August 2014| PDF Full-text (1069 KB) | Supplementary Files
Review: Interplay between Dioxin-Mediated Signaling and Circadian Clock: A Possible Determinant in Metabolic Homeostasis
Int. J. Mol. Sci. 2014, 15(7), 11700-11712; doi:10.3390/ijms150711700
Received: 22 April 2014; in revised form: 13 June 2014 / Accepted: 17 June 2014 / Published: 1 July 2014| PDF Full-text (970 KB) | HTML Full-text | XML Full-text
Int. J. Mol. Sci. 2014, 15(6), 11100-11110; doi:10.3390/ijms150611100
Received: 16 April 2014; in revised form: 27 May 2014 / Accepted: 7 June 2014 / Published: 19 June 2014| PDF Full-text (1081 KB) | HTML Full-text | XML Full-text
Review: The Role of AhR in Autoimmune Regulation and Its Potential as a Therapeutic Target against CD4 T Cell Mediated Inflammatory Disorder
Int. J. Mol. Sci. 2014, 15(6), 10116-10135; doi:10.3390/ijms150610116
Received: 17 February 2014; in revised form: 26 March 2014 / Accepted: 27 March 2014 / Published: 5 June 2014| PDF Full-text (484 KB) | HTML Full-text | XML Full-text
Article: Aryl Hydrocarbon Receptor Repressor and TiPARP (ARTD14) Use Similar, but also Distinct Mechanisms to Repress Aryl Hydrocarbon Receptor Signaling
Int. J. Mol. Sci. 2014, 15(5), 7939-7957; doi:10.3390/ijms15057939
Received: 9 April 2014; Accepted: 23 April 2014 / Published: 6 May 2014| PDF Full-text (1011 KB) | HTML Full-text | XML Full-text
Review: Association of Dioxin and Other Persistent Organic Pollutants (POPs) with Diabetes: Epidemiological Evidence and New Mechanisms of Beta Cell Dysfunction
Int. J. Mol. Sci. 2014, 15(5), 7787-7811; doi:10.3390/ijms15057787
Received: 19 February 2014; in revised form: 16 April 2014 / Accepted: 21 April 2014 / Published: 5 May 2014| PDF Full-text (374 KB) | HTML Full-text | XML Full-text
Article: The Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange
Int. J. Mol. Sci. 2014, 15(5), 7485-7499; doi:10.3390/ijms15057485
Received: 14 March 2014; in revised form: 11 April 2014 / Accepted: 14 April 2014 / Published: 30 April 2014| PDF Full-text (243 KB) | HTML Full-text | XML Full-text
Article: Functional Analysis of the Dioxin Response Elements (DREs) of the Murine CYP1A1 Gene Promoter: Beyond the Core DRE Sequence
Int. J. Mol. Sci. 2014, 15(4), 6475-6487; doi:10.3390/ijms15046475
Received: 3 January 2014; in revised form: 1 February 2014 / Accepted: 7 February 2014 / Published: 16 April 2014| PDF Full-text (748 KB) | HTML Full-text | XML Full-text | Supplementary Files
Last update: 11 August 2014