Next Article in Journal
Effects of Estradiol and Methoxychlor on Leydig Cell Regeneration in the Adult Rat Testis
Next Article in Special Issue
Aryl Hydrocarbon Receptor Repressor and TiPARP (ARTD14) Use Similar, but also Distinct Mechanisms to Repress Aryl Hydrocarbon Receptor Signaling
Previous Article in Journal
Development of Drug Delivery Systems Based on Layered Hydroxides for Nanomedicine
Previous Article in Special Issue
The Relationship between Dioxin Congeners in the Breast Milk of Vietnamese Women and Sister Chromatid Exchange
Article Menu

Export Article

Open AccessReview
Int. J. Mol. Sci. 2014, 15(5), 7787-7811; doi:10.3390/ijms15057787

Association of Dioxin and Other Persistent Organic Pollutants (POPs) with Diabetes: Epidemiological Evidence and New Mechanisms of Beta Cell Dysfunction

Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 55, Scuola Medica, 56126 Pisa, Italy
Received: 19 February 2014 / Revised: 16 April 2014 / Accepted: 21 April 2014 / Published: 5 May 2014
(This article belongs to the Special Issue Mechanisms of Toxicity of Dioxins and Related Compounds)
View Full-Text   |   Download PDF [374 KB, uploaded 19 June 2014]   |  

Abstract

The worldwide explosion of the rates of diabetes and other metabolic diseases in the last few decades cannot be fully explained only by changes in the prevalence of classical lifestyle-related risk factors, such as physical inactivity and poor diet. For this reason, it has been recently proposed that other “nontraditional” risk factors could contribute to the diabetes epidemics. In particular, an increasing number of reports indicate that chronic exposure to and accumulation of a low concentration of environmental pollutants (especially the so-called persistent organic pollutants (POPs)) within the body might be associated with diabetogenesis. In this review, the epidemiological evidence suggesting a relationship between dioxin and other POPs exposure and diabetes incidence will be summarized, and some recent developments on the possible underlying mechanisms, with particular reference to dioxin, will be presented and discussed. View Full-Text
Keywords: dioxin; diabetes; endocrine disruptors; persistent organic pollutants; beta cells; insulin secretion dioxin; diabetes; endocrine disruptors; persistent organic pollutants; beta cells; insulin secretion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

De Tata, V. Association of Dioxin and Other Persistent Organic Pollutants (POPs) with Diabetes: Epidemiological Evidence and New Mechanisms of Beta Cell Dysfunction. Int. J. Mol. Sci. 2014, 15, 7787-7811.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top