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Int. J. Mol. Sci. 2014, 15(6), 11100-11110; doi:10.3390/ijms150611100
Review

Coactivator Recruitment of AhR/ARNT1

* ,
 and *
Received: 16 April 2014; in revised form: 27 May 2014 / Accepted: 7 June 2014 / Published: 19 June 2014
(This article belongs to the Special Issue Mechanisms of Toxicity of Dioxins and Related Compounds)
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Abstract: A common feature of nuclear receptors (NRs) is the transformation of external cell signals into specific transcriptions of the signal molecule. Signal molecules function as ligands for NRs and, after their uptake, activated NRs form homo- or heterodimers at promoter recognition sequences of the specific genes in the nucleus. Another common feature of NRs is their dependence on coactivators, which bridge the basic transcriptional machinery and other cofactors to the target genes, in order to initiate transcription and to unwind histone-bound DNA for exposing additional promoter recognition sites via their histone acetyltransferase (HAT) function. In this review, we focus on our recent findings related to the recruitment of steroid receptor coactivator 1 (SRC1/NCoA1) by the estrogen receptor-α (ERα) and by the arylhydrocarbon receptor/arylhydrocarbon receptor nuclear translocator 1 (AhR/ARNT1) complex. We also describe the extension of our previously published findings regarding the binding between ARNT1.1 exon16 and SRC1e exon 21, via in silico analyses of androgen receptor (AR) NH2-carboxyl-terminal interactions, the results of which were verified by in vitro experiments. Based on these data, we suggest a newly derived tentative binding site of nuclear coactivator 2/glucocorticoid receptor interacting protein-1/transcriptional intermediary factor 2 (NCOA-2/ GRIP-1/TIF-2) for ARNT1.1 exon 16. Furthermore, results obtained by immunoprecipitation have revealed a second leucine-rich binding site for hARNT1.1 exon 16 in SRC1e exon 21 (LSSTDLL). Finally, we discuss the role of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as an endocrine disruptor for estrogen related transcription.
Keywords: SRC1; NCoA2; AhR; ARNT; TCDD; ER; AR SRC1; NCoA2; AhR; ARNT; TCDD; ER; AR
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Endler, A.; Chen, L.; Shibasaki, F. Coactivator Recruitment of AhR/ARNT1. Int. J. Mol. Sci. 2014, 15, 11100-11110.

AMA Style

Endler A, Chen L, Shibasaki F. Coactivator Recruitment of AhR/ARNT1. International Journal of Molecular Sciences. 2014; 15(6):11100-11110.

Chicago/Turabian Style

Endler, Alexander; Chen, Li; Shibasaki, Futoshi. 2014. "Coactivator Recruitment of AhR/ARNT1." Int. J. Mol. Sci. 15, no. 6: 11100-11110.



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