Special Issue "Renal Toxicology—Epidemiology and Mechanisms"
Deadline for manuscript submissions: closed (15 July 2014)
Prof. Dr. Gary O. Rankin
Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, One John Marshall Drive, Huntington, WV 25755, USA
Interests: nephrotoxicity mechanisms; renal bioactivation of toxicants; structure-toxicity relationships
The kidney is a target for many types of chemicals including drugs, agricultural agents, industrial chemicals and environmental pollutants. While an important function of the kidney is to eliminate xenobiotics and their metabolites, the kidney also has the ability to accumulate and concentrate chemicals to toxic levels via renal transport systems and urinary concentrating mechanisms. The kidneys can also bioactivate chemicals via a variety of enzyme systems to toxic metabolites that cause acute and/or chronic renal injury. Recent studies on genetic polymorphisms are also beginning to provide some insight into nephrotoxic mechanisms. However, for many nephrotoxicants, the mechanisms and contributing renal factors that lead to renal injury are poorly understood. Epidemiological studies have also revealed increased renal injury due to exposure to therapeutic agents as well as chemicals in the environment, and provided insight into the nephrotoxic potential of various chemicals and susceptible human populations. Nonetheless, additional epidemiological information is needed for many renal toxicants. Articles in this special issue will address research directed toward defining mechanisms and contributing factors leading to renal toxicity. In addition, this special issue will address epidemiological information related to nephrotoxicity related to chemical exposure.
Prof. Dr. Gary O. Rankin
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- nephrotoxic mechanisms
- bioactivation of nephrotoxicants
- nephrotoxic epidemiology
Article: Transition from Cyclosporine-Induced Renal Dysfunction to Nephrotoxicity in an in Vivo Rat Model
Int. J. Mol. Sci. 2014, 15(5), 8979-8997; doi:10.3390/ijms15058979
Received: 7 April 2014; in revised form: 5 May 2014 / Accepted: 13 May 2014 / Published: 20 May 2014| PDF Full-text (2146 KB) | HTML Full-text | XML Full-text
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: The Aging Kidney: Increased Susceptibility to Nephrotoxicity
Authors: Alan Parrish, Medical Pharmacology and Physiology, University of Missouri School of Medicine
Abstract: Three decades have past since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models has been strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including alterations in blood flow, antioxidant status, apoptosis, inflammation and decreased repair.
Last update: 20 March 2014