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Int. J. Mol. Sci. 2014, 15(9), 15358-15376; doi:10.3390/ijms150915358

The Aging Kidney: Increased Susceptibility to Nephrotoxicity

1
Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
2
Renal Division and Biomedical Engineering Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
3
Department of Medical Pharmacology and Physiology, School of Medicine, University of Missouri, Columbia, MO 65212, USA
*
Author to whom correspondence should be addressed.
Received: 25 June 2014 / Revised: 12 August 2014 / Accepted: 18 August 2014 / Published: 1 September 2014
(This article belongs to the Special Issue Renal Toxicology—Epidemiology and Mechanisms)
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Abstract

Three decades have passed since a series of studies indicated that the aging kidney was characterized by increased susceptibility to nephrotoxic injury. Data from these experimental models is strengthened by clinical data demonstrating that the aging population has an increased incidence and severity of acute kidney injury (AKI). Since then a number of studies have focused on age-dependent alterations in pathways that predispose the kidney to acute insult. This review will focus on the mechanisms that are altered by aging in the kidney that may increase susceptibility to injury, including hemodynamics, oxidative stress, apoptosis, autophagy, inflammation and decreased repair. View Full-Text
Keywords: aging; acute kidney injury (AKI); chronic kidney disease (CKD); nephrotoxicity aging; acute kidney injury (AKI); chronic kidney disease (CKD); nephrotoxicity
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Wang, X.; Bonventre, J.V.; Parrish, A.R. The Aging Kidney: Increased Susceptibility to Nephrotoxicity. Int. J. Mol. Sci. 2014, 15, 15358-15376.

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