Special Issue "Frontiers of Radioimmunotherapy"
Deadline for manuscript submissions: closed (12 December 2014)
Radioimmunotherapy, which utilizes radiolabeled antibodies for targeting tumors, is now an established therapy for Non-Hodgkin lymphoma (NHL) patients. Clinical research is still on-going to further improve the therapy for these patients (e.g., by attempting to prolong the duration of the clinical response).
The majority of the current pre-clinical radioimmunotherapy research aims at transferring the clinical success of treating lymphoma to treating solid tumors. Solid tumors are generally more radioresistant than NHL and require higher absorbed doses for therapeutic effect. Poor tumor accretion and the unfavorable pharmacokinetics of radiolabeled antibodies are major impediments that limit the efficacy of radioimmunotherapy in solid tumors. Ways of increasing the therapeutic outcome may involve pretargeting (where an unlabeled antibody construct is followed by a radiolabeled low molecular weight component that binds to the antibody construct), fractionated radioimmunotherapy, and the use of alpha-particle emitting radionuclides that have a higher radiobiological effect than that of the generally used beta-particle emitters. Radioimmunotherapy with alpha-particle emitters has been proposed for treating disseminated or residual diseases (due the short range of the particles).
Clinically, the consensus is that radioimmunotherapy is best used to treat small tumors (instead of bulky diseases). An interesting area for clinical research is the evaluation of combining radioimmunotherapy with other modalities (e.g. chemotherapy, tyrosine kinase inhibitors or immunotherapy).
The articles in this Special Issue of IJMS will cover a broad range of topics, from both pre-clinical and clinical research, which concern the improvement of radioimmunotherapy, so as to give the reader an update on the latest developments.
Dr. Rune Nilsson
Dr. Sophie E. Eriksson
Manuscript Submission Information
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- radionuclide therapy
- alpha emitter
- beta emitter
- tumor therapy