Special Issue "Nanotoxicology and Lung Diseases"
Deadline for manuscript submissions: closed (15 October 2014)
Prof. Dr. James C. Bonner (Website)
Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, 27695, USA
Interests: cellular and molecular mechanisms through which toxic environmental agents cause lung diseases; especially pulmonary fibrosis and asthma; lung fibrosis; asthma; nanotoxicology; metals; particles; fibers
The nanotechnology industry is rapidly developing, resulting in the production of a variety of engineered nanomaterials (ENMs) for a variety of applications. These ENMs include carbon nanotubes and metal or metal oxide nanoparticles such as zinc, titanium, cerium and silver that are incorporated into consumer products or encountered in occupational settings. Some of these novel engineered nanostructures represent a potential human health risk, due to the possibility of inhalation exposure and evidence that the lung, as well as other systemic sites, are targets for hazardous effects. Articles in this special issue will address cutting edge research aimed at elucidating the mechanisms through which ENMs cause pulmonary disease in rodents after lung exposure. Inhalation studies in rodents show that ENMs deposit within the distal regions in the lungs and cause inflammation, fibrosis, or alter immune responses. Because novel engineering methodology is resulting in the production of an increasing complexity of ENM structures that vary in toxicological activity, this issue will also address high content screening for the development of structure-activity relationships relevant to inhalation toxicity and safer design of nanoparticles. This will include exploration of factors that mediate toxic effects such as high aspect ratio, durability, and residual metal content. Finally, we will address how susceptibility factors, both genetic and environmental, determine pulmonary and systemic toxicity to ENMs.
Prof. Dr. James C. Bonner
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.