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Int. J. Mol. Sci. 2014, 15(1), 878-894; doi:10.3390/ijms15010878
Article

Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials

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Received: 11 December 2013; in revised form: 26 December 2013 / Accepted: 3 January 2014 / Published: 9 January 2014
(This article belongs to the Special Issue Nanotoxicology and Lung Diseases)
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Abstract: Fractional exhaled nitric oxide (FENO) measurement is a useful diagnostic test of airway inflammation. However, there have been few studies of FENO in workers exposed to nanomaterials. The purpose of this study was to examine the effect of nanoparticle (NP) exposure on FENO and to assess whether the FENO is increased in workers exposed to nanomaterials (NM). In this study, both exposed workers and non-exposed controls were recruited from NM handling plants in Taiwan. A total of 437 subjects (exposed group = 241, non-exposed group = 196) completed the FENO and spirometric measurements from 2009–2011. The authors used a control-banding (CB) matrix to categorize the risk level of each participant. In a multivariate linear regression analysis, this study found a significant association between risk level 2 of NP exposure and FENO. Furthermore, asthma, allergic rhinitis, peak expiratory flow rate (PEFR), and NF-κB were also significantly associated with FENO. When the multivariate logistic regression model was adjusted for confounders, nano-TiO2 in all of the NM exposed categories had a significantly increased risk in FENO > 35 ppb. This study found associations between the risk level of NP exposure and FENO (particularly noteworthy for Nano-TiO2). Monitoring FENO in the lung could open up a window into the role nitric oxide (NO) may play in pathogenesis.
Keywords: nanoparticles; nanomaterials; workers’s respiratory health; airway inflammation; Fractional exhaled nitric oxide; occupational epidemiology nanoparticles; nanomaterials; workers’s respiratory health; airway inflammation; Fractional exhaled nitric oxide; occupational epidemiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wu, W.-T.; Liao, H.-Y.; Chung, Y.-T.; Li, W.-F.; Tsou, T.-C.; Li, L.-A.; Lin, M.-H.; Ho, J.-J.; Wu, T.-N.; Liou, S.-H. Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials. Int. J. Mol. Sci. 2014, 15, 878-894.

AMA Style

Wu W-T, Liao H-Y, Chung Y-T, Li W-F, Tsou T-C, Li L-A, Lin M-H, Ho J-J, Wu T-N, Liou S-H. Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials. International Journal of Molecular Sciences. 2014; 15(1):878-894.

Chicago/Turabian Style

Wu, Wei-Te; Liao, Hui-Yi; Chung, Yu-Teh; Li, Wan-Fen; Tsou, Tsui-Chun; Li, Lih-Ann; Lin, Ming-Hsiu; Ho, Jiune-Jye; Wu, Trong-Neng; Liou, Saou-Hsing. 2014. "Effect of Nanoparticles Exposure on Fractional Exhaled Nitric Oxide (FENO) in Workers Exposed to Nanomaterials." Int. J. Mol. Sci. 15, no. 1: 878-894.



Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert