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Special Issue "Guided Amphiphile and Lipid Membrane Self-Assembly"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biomaterial Sciences".

Deadline for manuscript submissions: closed (31 May 2017)

Special Issue Editor

Guest Editor
Prof. Dr. Erik Reimhult

Head, Department of Nanobiotechnology, Instititute for Biologocially inspired materials, University of Natural Resources and Life Sciences Vienna, Muthgasse 11-II, A-1190 Vienna, Austria
Website1 | Website2 | E-Mail
Interests: colloidal science; surface science; liquid interfaces; nanoscience; nanoparticles; lipid membranes; polymer brushes; biointerfaces; biosensors

Special Issue Information

Dear Colleagues,

The self-assembly of natural and synthetic amphiphiles fulfills important technical roles in many existing and emerging, not the least nanotechnological, applications. The basic framework to understand amphiphile assembly was developed decades ago. However, the sheer number of variations in amphiphile composition and applications ensures that we have only just begun to understand these processes to the level of detail at which our understanding allows us to build complex structures and functions using amphiphiles that rival those found in, e.g., biological systems.

To this Special Issue, we invite contributions that study the synthesis and assembly of amphiphile superstructures that mimic, can perform or help us understand biological functions. We will cover a selection of recent research topics and current review articles that can either be theoretical or experimental works. Examples are assembly of synthetic organelles and supported or vesicular membranes for incorporating proteins. It can also be the interaction of lipids and lipid-like surfactants with solid and liquid interfaces, from macroscopic systems to droplets and nanoparticles, that have importance for the development of tools for drug delivery or to study nanotoxicology. In particular, we welcome studies of interfacial properties and dynamic phase behavior that utilize the unique properties of amphiphiles in a controlled way, inspired by the multitude of such processes in biology.

Prof. Dr. Erik Reimhult
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Amphiphile self-assembly
  • Lipid
  • Block co-polymer
  • Vesicle
  • Liposome
  • Supported bilayer
  • Surface assembly
  • Solid
  • Liquid

Published Papers (1 paper)

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Research

Open AccessArticle Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice
Int. J. Mol. Sci. 2017, 18(10), 2177; doi:10.3390/ijms18102177
Received: 25 September 2017 / Revised: 13 October 2017 / Accepted: 15 October 2017 / Published: 18 October 2017
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Abstract
Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain
[...] Read more.
Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) and Southern blotting were used to identify transgenic safflowers carrying a gene encoding an oleosin-rhFGF-10 fusion protein. The size and structural integrity of oleosin-rhFGF-10 in oil bodies extracted from transgenic safflower seeds was characterized by polyacrylamide gel electrophoresis and western blotting. Oil body extracts containing oleosin-rhFGF-10 were topically applied to mouse skin. The absorption of oleosin-rhFGF-10 was studied by immunohistochemistry. Its efficiency in promoting wound healing and hair regeneration were evaluated in full thickness wounds and hair growth assays. We identified a safflower line that carried the transgene and expressed a 45 kDa oleosin-rhFGF-10 protein. Oil body-bound oleosin-rhFGF-10 was absorbed by the skin with higher efficiency and speed compared with prokaryotically-expressed rhFGF-10. Oleosin-rhFGF-10 also enhanced wound closure and promoted hair growth better than rhFGF-10. The application of oleosin-rhFGF-10 in oil bodies promoted its delivery through the skin, providing a basis for improved therapeutic effects in enhancing wound healing and hair growth. Full article
(This article belongs to the Special Issue Guided Amphiphile and Lipid Membrane Self-Assembly)
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