E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Special Issue "Surface Modification and Assembly of Magnetic Nanoparticle Materials"

Quicklinks

A special issue of Materials (ISSN 1996-1944).

Deadline for manuscript submissions: closed (31 March 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Erik Reimhult

Head, Department of Nanobiotechnology, Instititute for Biologocially inspired materials, University of Natural Resources and Life Sciences Vienna, Muthgasse 11-II, A-1190 Vienna, Austria
Website1 | Website2 | E-Mail
Interests: colloidal science; surface science; liquid interfaces; nanoscience; nanoparticles; lipid membranes; polymer brushes; biointerfaces; biosensors

Published Papers (1 paper)

View options order results:
result details:
Displaying articles 1-1
Export citation of selected articles as:

Research

Open AccessArticle Efficacy and Durability in Direct Labeling of Mesenchymal Stem Cells Using Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Organosilica, Dextran, and PEG Coatings
Materials 2011, 4(4), 703-715; doi:10.3390/ma4040703
Received: 7 March 2011 / Revised: 29 March 2011 / Accepted: 2 April 2011 / Published: 7 April 2011
Cited by 15 | PDF Full-text (437 KB) | HTML Full-text | XML Full-text
Abstract
We herein report a comparative study of mesenchymal stem cell (MSC) labeling using spherical superparamagnetic iron oxide (SPIO) nanoparticles containing different coatings, namely, organosilica, dextran, and poly(ethylene glycol) (PEG). These nanomaterials possess a similar SPIO core size of 6–7 nm. Together with their
[...] Read more.
We herein report a comparative study of mesenchymal stem cell (MSC) labeling using spherical superparamagnetic iron oxide (SPIO) nanoparticles containing different coatings, namely, organosilica, dextran, and poly(ethylene glycol) (PEG). These nanomaterials possess a similar SPIO core size of 6–7 nm. Together with their coatings, the overall sizes are 10–15 nm for all SPIO@SiO2, SPIO@dextran, and SPIO@PEG nanoparticles. These nanoparticles were investigated for their efficacies to be uptaken by rabbit bone marrow-derived MSCs without any transfecting agent. Experimentally, both SPIO@SiO2 and SPIO@PEG nanoparticles could be successfully uptaken by MSCs while the SPIO@dextran nanoparticles demonstrated limited labeling efficiency. The labeling durability of SPIO@SiO2 and SPIO@PEG nanoparticles in MSCs after three weeks of culture were compared by Prussian blue staining tests. SPIO@SiO2 nanoparticles demonstrated more blue staining than SPIO@PEG nanoparticles, rendering them better materials for MSCs labeling by direct uptake when durable intracellullar retention of SPIO is desired. Full article
(This article belongs to the Special Issue Surface Modification and Assembly of Magnetic Nanoparticle Materials)

Journal Contact

MDPI AG
Materials Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
materials@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Materials
Back to Top