Special Issue "Dental Materials"
Deadline for manuscript submissions: closed (30 June 2011)
Prof. Dr. Jorge Perdigão
University of Minnesota, Department of Restorative Sciences, Division of Operative Dentistry, 515 SE Delaware St, 8-450 Moos Tower, Minneapolis, MN 55455, USA
Dental research has been transitioning gradually from the classical Restorative Dentistry to Regenerative Dentistry. Regeneration of a functional tooth is a promising strategy for replacing an irreversibly diseased tooth. Pulp-like tissue can now be regenerated in root canal space by stem cells and give rise to odontoblast-like cells producing dentin-like tissue. Three-dimensional porous scaffolds made of mineralized type I collagen mimic the composition of extracellular matrix ofbone and can therefore have the potential of being used as a biomimetic graft material. Additionally, the role of RNA interference (RNAi) and RNA activation (RNAa) may prove to be crucial to treat or prevent dental anomalies and periodontal disease.
The role of metalloproteinases (or MMP’s) inhibitors in preventing the degradation of dentinal collagen fibers has been recently highlighted in dentin adhesion. Other promising areas of research in dental adhesion are the application of colloidal platinum nanoparticles, and guided tissue mineralization to re-mineralize areas etched by phosphoric acid but not infiltrated by the adhesive.
Some of the dental materials recently introduced - low-shrinkage resin composites and Y-TZP-based fixed prostheses - have changed some of the classical concepts of clinical dentistry.
For the first time in 40 years, dentists are using a non-BisGMA resin composite. Shrinkage stresses are reduced with the new silorane-based resin composites. The relevance of using low- or no-shrinking composite materials is that internal stresses occur during the polymerization of all dental composites due to a volumetric contraction. These shrinkage stresses may cause interfacial failures between the restoration and the tooth structure.
Yttria-stabilized tetragonal zirconia (Y-TZP) and titanium implants have been increasingly used in Dentistry. Y-TZP is used as the infrastructure for crowns, bridges and implant abutments. Research in Clinical Orthopedics has shown that Y-TZP used in hip arthroplasties may undergo transformation under mechanical and/or hydrothermal stress, with degradation of mechanical and tribologic properties. It is not known if these alterations also occur in Y-TZP dental restorations.
Prof. Dr. Jorge Perdigão
- nanotechnology in Dentistry
- dental pulp & regeneration
- scaffold materials
- stem cells in dentistry
- dental tissue bioengineering
- RNA interference
- dentin ultrastructure & adhesion
- dentin MMP's & collagen
- non-shrinking composite materials
- biodegradation of Y-TZP
- optimization of dental implant surfaces
Review: Surface Modification of Biomedical and Dental Implants and the Processes of Inflammation, Wound Healing and Bone Formation
Int. J. Mol. Sci. 2010, 11(1), 354-369; doi:10.3390/ijms11010354
Received: 24 December 2009; in revised form: 18 January 2010 / Accepted: 20 January 2010 / Published: 25 January 2010| Cited by 16 | PDF Full-text (130 KB) | HTML Full-text | XML Full-text
Article: Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1
Int. J. Mol. Sci. 2010, 11(4), 1458-1470; doi:10.3390/ijms11041458
Received: 23 February 2010; in revised form: 23 March 2010 / Accepted: 23 March 2010 / Published: 2 April 2010| Cited by 4 | PDF Full-text (380 KB) | HTML Full-text | XML Full-text
Review: Dental Implant Systems
Int. J. Mol. Sci. 2010, 11(4), 1580-1678; doi:10.3390/ijms11041580
Received: 20 February 2010; in revised form: 28 March 2010 / Accepted: 30 March 2010 / Published: 12 April 2010| Cited by 7 | PDF Full-text (637 KB) | HTML Full-text | XML Full-text
Int. J. Mol. Sci. 2010, 11(6), 2523-2545; doi:10.3390/ijms11062523
Received: 19 March 2010; in revised form: 5 June 2010 / Accepted: 7 June 2010 / Published: 17 June 2010| Cited by 8 | PDF Full-text (2381 KB) | HTML Full-text | XML Full-text
Article: Antifungal Activity of Denture Soft Lining Material Modified by Silver Nanoparticles—A Pilot Study
Int. J. Mol. Sci. 2011, 12(7), 4735-4744; doi:10.3390/ijms12074735
Received: 23 June 2011; in revised form: 14 July 2011 / Accepted: 18 July 2011 / Published: 22 July 2011| Cited by 6 | PDF Full-text (1907 KB) | HTML Full-text | XML Full-text
Int. J. Mol. Sci. 2011, 12(8), 5330-5338; doi:10.3390/ijms12085330
Received: 28 June 2011; in revised form: 12 July 2011 / Accepted: 12 August 2011 / Published: 18 August 2011| Cited by 2 | PDF Full-text (743 KB) | HTML Full-text | XML Full-text
Last update: 7 August 2014