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Int. J. Mol. Sci. 2010, 11(1), 354-369; doi:10.3390/ijms11010354

Surface Modification of Biomedical and Dental Implants and the Processes of Inflammation, Wound Healing and Bone Formation

Dows Institute for Dental Research, College of Dentistry, University of Iowa, IA 52242, USA
Received: 24 December 2009 / Revised: 18 January 2010 / Accepted: 20 January 2010 / Published: 25 January 2010
(This article belongs to the Special Issue Dental Materials)
View Full-Text   |   Download PDF [130 KB, uploaded 19 June 2014]


Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces. View Full-Text
Keywords: implant; surfaces; wound healing; macrophage implant; surfaces; wound healing; macrophage
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Stanford, C.M. Surface Modification of Biomedical and Dental Implants and the Processes of Inflammation, Wound Healing and Bone Formation. Int. J. Mol. Sci. 2010, 11, 354-369.

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