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• Chladek, G
• Mertas, A
• Barszczewska-Rybarek, I
• Nalewajek, T
• Żmudzki, J
• Król, W
• Łukaszczyk, J
• [+] on Google Scholar
• Chladek, G
• Mertas, A
• Barszczewska-Rybarek, I
• Nalewajek, T
• Żmudzki, J
• Król, W
• Łukaszczyk, J
• [+] on PubMed
• Chladek, G
• Mertas, A
• Barszczewska-Rybarek, I
• Nalewajek, T
• Żmudzki, J
• Król, W
• Łukaszczyk, J

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Int. J. Mol. Sci. 2011, 12(7), 4735-4744; doi:10.3390/ijms12074735

Article

Antifungal Activity of Denture Soft Lining Material Modified by Silver Nanoparticles—A Pilot Study

Grzegorz Chladek ^1,* , Anna Mertas ² , Izabela Barszczewska-Rybarek ³ , Teresa Nalewajek ² , Jarosław Żmudzki ¹ , Wojciech Król ²  and Jan Łukaszczyk ³

¹ Department of Materials Technology, Silesian University of Technology, ul. Krasińskiego 8, 40-019 Katowice, Poland ² Chair and Department of Microbiology and Immunology in Zabrze, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland ³ Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland

* Author to whom correspondence should be addressed.

Received: 23 June 2011; in revised form: 14 July 2011 / Accepted: 18 July 2011 / Published: 22 July 2011

(This article belongs to the Special Issue Dental Materials)

Download PDF Full-Text [1907 KB, uploaded 22 July 2011 14:26 CEST]

Abstract: Soft liner materials in oral cavity environments are easily colonized both by fungi and dental plaque. These factors are the cause of mucosal infections. The microorganism that most frequently colonizes soft liner materials is Candida albicans. Colonization occurs on the surface of materials and within materials. A solution to this problem might involve modification of soft liner materials with silver nanoparticles (AgNPs). In this article, we present results showing the antifungal efficacy of silicone soft lining materials modified with AgNPs. The modification process was conducted by dissolving both material components (base and catalyst) in a colloidal solution of AgNPs and evaporating the solvent. Composites with various AgNP concentrations (10, 20, 40, 80, 120 and 200 ppm) were examined. The in vitro antifungal efficacy (AFE) of composite samples was 16.3% to 52.5%.

Keywords: nanotechnology in dentistry; silver nanoparticles; antifungal; dental materials; soft liner; Candida albicans

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