Special Issue "Identification and Roles of the Structure of DNA"


A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry, Molecular Biology and Biophysics".

Deadline for manuscript submissions: closed (30 May 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Youri Timsit
CNRS, Aix-Marseille Université, IGS UMR7256, FR-13288 Marseille, France
Website: http://www.igs.cnrs-mrs.fr/spip.php?article219&lang=fr
E-Mail: Youri.Timsit@igs.cnrs-mrs.fr
Interests: higher-order DNA structures; chirality; chromatin folding; topology; DNA unwinding; DNA self-assembly; DNA dynamics; DNA flexibility; kinking; base-pair opening

Special Issue Information

Dear Colleagues,

Since its discovery in 1953, the double helix has been mainly considered as a passive support of the genetic information. However, this current view overlooks subtle properties of DNA that possesses all the attributes to be an active player in the cell. Indeed, a complex interplay between the nucleotide sequence and its molecular environment generates DNA structures that may play critical roles in key cellular functions. From local base-pair opening to global topology, the double helix is finely tuned to solve the multiple tasks required to generate and regulate the genetic information. For example, the DNA structure may directly influence the rate of replication errors within the active site of DNA polymerases, but it can also direct chiral DNA–DNA interactions that help to locally sense the global DNA topology by type II topoisomerases. Understanding how DNA may actively contribute to generate, control and spatially organize the genetic information, requires deciphering the complex relationships between the DNA sequence, structure, dynamics and the electrostatic environment. The aim of this Special Issue is to explore these new concepts in combining experimental and theoretical studies.

Dr. Youri Timsit
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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  • Higher-order DNA structures
  • chirality
  • chromatin folding
  • topology
  • DNA unwinding
  • DNA self-assembly
  • DNA dynamics
  • DNA flexibility
  • kinking
  • base-pair opening

Published Papers (5 papers)

by , , , , ,  and
Int. J. Mol. Sci. 2014, 15(7), 13111-13122; doi:10.3390/ijms150713111
Received: 31 May 2014; in revised form: 9 July 2014 / Accepted: 14 July 2014 / Published: 23 July 2014
Show/Hide Abstract | PDF Full-text (1234 KB)

by  and
Int. J. Mol. Sci. 2014, 15(7), 12335-12363; doi:10.3390/ijms150712335
Received: 21 May 2014; in revised form: 1 July 2014 / Accepted: 1 July 2014 / Published: 14 July 2014
Show/Hide Abstract | PDF Full-text (1215 KB)
abstract graphic

by ,  and
Int. J. Mol. Sci. 2014, 15(7), 11799-11816; doi:10.3390/ijms150711799
Received: 30 May 2014; in revised form: 23 June 2014 / Accepted: 25 June 2014 / Published: 3 July 2014
Show/Hide Abstract | PDF Full-text (1865 KB) | Supplementary Files
abstract graphic

by , , ,  and
Int. J. Mol. Sci. 2014, 15(6), 10835-10854; doi:10.3390/ijms150610835
Received: 24 March 2014; in revised form: 12 May 2014 / Accepted: 10 June 2014 / Published: 16 June 2014
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by , ,  and
Int. J. Mol. Sci. 2014, 15(2), 1901-1914; doi:10.3390/ijms15021901
Received: 5 December 2013; in revised form: 31 December 2013 / Accepted: 7 January 2014 / Published: 27 January 2014
Show/Hide Abstract | PDF Full-text (4287 KB) | HTML Full-text | XML Full-text

Last update: 6 November 2013

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