Special Issue "Identification and Roles of the Structure of DNA"
Deadline for manuscript submissions: closed (30 May 2014)
Prof. Dr. Youri Timsit
CNRS, Aix-Marseille Université, IGS UMR7256, FR-13288 Marseille, France
Interests: higher-order DNA structures; chirality; chromatin folding; topology; DNA unwinding; DNA self-assembly; DNA dynamics; DNA flexibility; kinking; base-pair opening
Since its discovery in 1953, the double helix has been mainly considered as a passive support of the genetic information. However, this current view overlooks subtle properties of DNA that possesses all the attributes to be an active player in the cell. Indeed, a complex interplay between the nucleotide sequence and its molecular environment generates DNA structures that may play critical roles in key cellular functions. From local base-pair opening to global topology, the double helix is finely tuned to solve the multiple tasks required to generate and regulate the genetic information. For example, the DNA structure may directly influence the rate of replication errors within the active site of DNA polymerases, but it can also direct chiral DNA–DNA interactions that help to locally sense the global DNA topology by type II topoisomerases. Understanding how DNA may actively contribute to generate, control and spatially organize the genetic information, requires deciphering the complex relationships between the DNA sequence, structure, dynamics and the electrostatic environment. The aim of this Special Issue is to explore these new concepts in combining experimental and theoretical studies.
Dr. Youri Timsit
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access monthly journal published by MDPI.
- Higher-order DNA structures
- chromatin folding
- DNA unwinding
- DNA self-assembly
- DNA dynamics
- DNA flexibility
- base-pair opening