Special Issue "Immuno- and Neuropathogenesis of HIV Disease: Mechanisms, Prevention, Treatment, and Cure"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 October 2016)
Prof. Dr. Brian Wigdahl
Professor and Chair, Department of Microbiology and Immunology; Director, Institute for Molecular and Medicine and Infectious Disease; Director, Center for Molecular Virology and Translational Neuroscience, Drexel University College of Medicine, Philadelphia, PA, 19102, USA
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Interests: immuno- and neuropathogenesis of HIV-1, HTLV-1, and HSV infection; Transcriptional regulation of retroviral gene expression; Viral genetic variation, viral reservoirs, latency, activation; Prevention, treatment, and cure of retrovirus and herpesvirus disease
The fourth decade in the fight against the human immunodeficiency virus (HIV) is now in progress and the acquired immunodeficiency syndrome (AIDS) pandemic, with its many associated comorbidities, continues to present a major health crisis worldwide. Encouraging, is that, in the industrialized world, ever increasing efficacious therapeutic combination regimens have converted a hopeless and devastating clinical picture to one that is getting closer to a long-term but clinically manageable chronic human disease with still an all-to-often lethal endpoint. In contrast, in economically challenged regions of the world, HIV infection and the associated clinical problems remain an acute life threatening pandemic in the absence of the most effective combination therapies, state-of-the-art clinical care, and an effective vaccine. Despite the significant progress with regard to understanding the pathogenesis of HIV/AIDS and the development of more than 30 FDA approved therapeutic agents that have been used in numerous and very effective combination therapies to dramatically extend the average lifespan of the HIV-infected patient population, there are many avenues of research that are very needed to optimally prevent, diagnose, and treat HIV disease, and cure the HIV-infected patient population across the many subtypes of HIV infection around the world. This Special Issue will center on reviews and primary data manuscripts that focus on defining (1) new cellular and viral targets to prevent and further control HIV replication and minimize long-term toxicity; (2) viral reservoirs in the periphery including cells involved in harboring latent viral genomes, molecular mechanisms of latency, and activating and non-activating viral genotypes; (3) mechanisms to cure latently infected or activated cells; (4) events involved in transmigration of HIV-infected cells across the blood-brain barrier; (5) mechanisms that result in disruption of the blood-brain barrier; (6) interactions between the astrocytes, pericytes, brain endothelial cells and neurons that lead to central nervous system (CNS) dysfunction; (7) the impact of HIV-infected microglial cells and other cells of the monocyte-macrophage lineage and their viral and cellular products on astrocyte-neuronal function that lead to impairment; (8) links between metabolic and vascular disease and HIV neuropathogenesis; and (9) the differential phenotypic and genotypic properties of HIV with respect to the spectrum of HIV CNS disease.
Prof. Dr. Brian Wigdahl
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Human immunodeficiency virus
- Acquired immunodeficiency syndrome
- HIV treatment and prevention
- Viral reservoirs
- Cell trafficking
- Genetic variation
- Genetic diversity
- Viral latency
- HIV cure
- HIV quasispecies
- Blood–brain barrier