Topical Collection "Hybrid Imaging in Medicine"


A topical collection in Diagnostics (ISSN 2075-4418).


Collection Editor
Prof. Dr. Andreas Kjaer
Department of Clinical Physiology, Nuclear Medicine & PET National University Hospital, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
Phone: +45 3545 4216
Fax: +45 3545 4015
Interests: molecular imaging; medical imaging; cancer; cardiovascular disease; PET; SPECT
Guest Editor
Prof. Dr. Gary Cook
Cancer (Imaging) Department, King's College London, Lambeth Wing, St Thomas', SE1 7EH, United Kingdom

Topical Collection Information

Dear Colleagues,

Medical imaging techniques are of paramount value in clinical medicine and as research tools. The techniques are rapidly improving and new techniques are continuously implemented.
Whereas every technique has advantages and shortcomings, imaging techniques are often complementary, and therefore, a current trend is the integration of different imaging techniques for hybrid imaging.
Examples of such synergistic hybrid imaging is PET/CT, which is now more common than PET-only scans. Recently, hybrid PET/MRI scanners have also been introduced in clinical use. Moreover, developments for combining ultrasonography with other modalities are on their way. Integration of morphological and functional imaging seems to be especially useful. However, combinations of several functional modalities may add value and allow for better tissue characterization.

This collection invites submission of both original and review papers within all aspects of hybrid imaging.

Prof. Dr. Andreas Kjaer
Prof. Dr. Gary Cook
Collection Editors

Manuscript Submission Information

Manuscripts for the topical collection can be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on this website. The topical collection considers regular research articles, short communications and review articles. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page.

Please visit the Instructions for Authors page before submitting a manuscript. For the first few issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • positron emission tomography
  • computed tomography (CT)
  • magnetic resonsnace imaging (MRI)
  • magnetic resonance spectroscopy (MRS)
  • ultrasonography
  • optical imaging
  • fluorescence
  • bioluminiscence
  • PET/CT

Published Papers (8 papers)

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2015  ( 5 papers )

2014  ( 3 papers )

by , , ,  and
Diagnostics 2015, 5(3), 369-371; doi:10.3390/diagnostics5030369
Received: 29 July 2015 / Revised: 19 August 2015 / Accepted: 20 August 2015 / Published: 28 August 2015
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by , , , , , ,  and
Diagnostics 2015, 5(3), 333-357; doi:10.3390/diagnostics5030333
Received: 16 June 2015 / Revised: 9 July 2015 / Accepted: 10 July 2015 / Published: 21 July 2015
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by  and
Diagnostics 2015, 5(3), 296-317; doi:10.3390/diagnostics5030296
Received: 2 June 2015 / Revised: 29 June 2015 / Accepted: 1 July 2015 / Published: 10 July 2015
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by  and
Diagnostics 2015, 5(3), 290-293; doi:10.3390/diagnostics5030290
Received: 23 June 2015 / Revised: 6 July 2015 / Accepted: 6 July 2015 / Published: 9 July 2015
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by , , , , , , ,  and
Diagnostics 2015, 5(3), 287-289; doi:10.3390/diagnostics5030287
Received: 13 May 2015 / Revised: 17 June 2015 / Accepted: 19 June 2015 / Published: 26 June 2015
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by ,  and
Diagnostics 2014, 4(3), 129-139; doi:10.3390/diagnostics4030129
Received: 19 May 2014 / Revised: 21 July 2014 / Accepted: 8 August 2014 / Published: 10 September 2014
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by ,  and
Diagnostics 2014, 4(2), 57-93; doi:10.3390/diagnostics4020057
Received: 2 February 2014 / Revised: 18 April 2014 / Accepted: 22 April 2014 / Published: 5 May 2014
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by , , , , ,  and
Diagnostics 2014, 4(1), 13-26; doi:10.3390/diagnostics4010013
Received: 29 January 2014 / Revised: 28 February 2014 / Accepted: 4 March 2014 / Published: 10 March 2014
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: The Use of Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy
Authors: Michael Ljungberg and Katarina Sjögreen Gleisner
Abstract: Radionuclide therapy aims to treat malignant disease by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. Radionuclides used are such that emit electrons or alpha particles as part of radioactive decay, thus imparting a local energy-deposition. The activity to administer to the individual patient can be tailored with regards to the risk of toxicity in normal organs, using absorbed dose planning. The scintillation camera, employed in planar- or SPECT mode imaging, generates images of the spatially and temporally varying activity distribution. Recent commercially available SPECT/CT systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and the highlights steps where hybrid imaging makes significant contributions.

Title: Role of hybrid molecular brain imaging in neuropsychiatric disorders
Burhan AM, Arena A, Subramanian P, Palaniappan L and Prato F
This is a focused review of imaging literature to scope the utility of hybrid molecular brain imaging in neuropsychiatric disorders. The review focuses on brain imaging modalities that utilize hybrid techniques to profile changes in brain molecular signal in combination with structural brain imaging. An overview of available hybrid molecular brain imaging technologies is followed by a review of the literature on current evidence for the utility of these technologies in understanding basic mechanisms of major neuropsychiatric disorders and their therapeutics.

Last update: 8 September 2015

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